Endosome maturation
J Huotari, A Helenius - The EMBO journal, 2011 - embopress.org
Being deeply connected to signalling, cell dynamics, growth, regulation, and defence,
endocytic processes are linked to almost all aspects of cell life and disease. In this review …
endocytic processes are linked to almost all aspects of cell life and disease. In this review …
The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death
The 26S proteasome is a large,∼ 2.5 MDa, multi-catalytic ATP-dependent protease complex
that serves as the degrading arm of the ubiquitin system, which is the major pathway for …
that serves as the degrading arm of the ubiquitin system, which is the major pathway for …
[HTML][HTML] Ubiquitin: same molecule, different degradation pathways
Ubiquitin is a common demoninator in the targeting of substrates to all three major protein
degradation pathways in mammalian cells: the proteasome, the lysosome, and the …
degradation pathways in mammalian cells: the proteasome, the lysosome, and the …
Molecular architecture and assembly of the eukaryotic proteasome
The eukaryotic ubiquitin-proteasome system is responsible for most aspects of regulatory
and quality-control protein degradation in cells. Its substrates, which are usually modified by …
and quality-control protein degradation in cells. Its substrates, which are usually modified by …
Oxidative stress-mediated regulation of proteasome complexes
CT Aiken, RM Kaake, X Wang, L Huang - Molecular & Cellular Proteomics, 2011 - ASBMB
Oxidative stress has been implicated in aging and many human diseases, notably
neurodegenerative disorders and various cancers. The reactive oxygen species that are …
neurodegenerative disorders and various cancers. The reactive oxygen species that are …
Structure, dynamics and function of the 26S proteasome
Y Mao - Macromolecular protein complexes III: structure and …, 2021 - Springer
The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …
Cross-linking of the endolysosomal system reveals potential flotillin structures and cargo
J Singh, H Elhabashy, P Muthukottiappan… - Nature …, 2022 - nature.com
Lysosomes are well-established as the main cellular organelles for the degradation of
macromolecules and emerging as regulatory centers of metabolism. They are of crucial …
macromolecules and emerging as regulatory centers of metabolism. They are of crucial …
Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway
Among the hallmarks of aged organisms are an accumulation of misfolded proteins and a
reduction in skeletal muscle mass (" sarcopenia"). We have examined the effects of aging …
reduction in skeletal muscle mass (" sarcopenia"). We have examined the effects of aging …
Governance of endocytic trafficking and signaling by reversible ubiquitylation
The endosomal pathway provides a major platform for ubiquitin-modifying enzymes, which
act upon membrane-associated proteins in transit. Ubiquitylated cargo proteins are …
act upon membrane-associated proteins in transit. Ubiquitylated cargo proteins are …
The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress
Oxidative stress has been implicated in multiple human neurological and other disorders.
Proteasomes are multi-subunit proteases critical for the removal of oxidatively damaged …
Proteasomes are multi-subunit proteases critical for the removal of oxidatively damaged …