Neutrophils are the most abundant circulating leukocyte within the blood stream and for
many years the dogma has been that these cells migrate rapidly into tissues in response to …

The half-life of human neutrophils is still controversial, with estimates ranging from 7–9 h to
3.75 days. This debate should be settled to understand neutrophil production in the bone …

Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare
primary immunodeficiency caused by gain-of-function mutations in the CXCR4 gene. We …

The view of neutrophils has shifted from simple phagocytic cells, whose main function is to
kill pathogens, to very complex cells that are also involved in immune regulation and tissue …

Following the FDA-approval of the hematopoietic stem cell (HSC) mobilizer plerixafor, orally
available and potent CXCR4 antagonists were pursued. One such proposition was …

Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a life-saving procedure
used for the treatment of selected hematological malignancies, inborn errors of metabolism …

Neutrophils, the most abundant type of granulocyte, are widely recognized as one of the
pivotal contributors to the acute inflammatory response. Initially, neutrophils were …

There is currently great interest in the development of cell-based therapies, particularly
those focused on the idea of exploiting systemically administered immune cells for …

Appropriate neutrophil function is essential for innate immune defence and to avoid
inflammatory pathology. Neutrophils can adapt their responses according to their …

Chemokines (chemotactic cytokines) play essential roles in developmental process, immune
cell trafficking, inflammation, immunity, angiogenesis, cellular homeostasis, aging, and …