End-to-end design of wearable sensors

HC Ates, PQ Nguyen, L Gonzalez-Macia… - Nature Reviews …, 2022 - nature.com
Wearable devices provide an alternative pathway to clinical diagnostics by exploiting
various physical, chemical and biological sensors to mine physiological (biophysical and/or …

Leveraging artificial intelligence in the fight against infectious diseases

F Wong, C de la Fuente-Nunez, JJ Collins - Science, 2023 - science.org
Despite advances in molecular biology, genetics, computation, and medicinal chemistry,
infectious disease remains an ominous threat to public health. Addressing the challenges …

A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution

T Zhang, R Deng, Y Wang, C Wu, K Zhang… - Nature Biomedical …, 2022 - nature.com
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
highlighted the need for versatile diagnostic assays that can discriminate among emerging …

Lateral flow test engineering and lessons learned from COVID-19

J Budd, BS Miller, NE Weckman, D Cherkaoui… - Nature Reviews …, 2023 - nature.com
The acceptability and feasibility of large-scale testing with lateral flow tests (LFTs) for clinical
and public health purposes has been demonstrated during the COVID-19 pandemic. LFTs …

Simplified Cas13-based assays for the fast identification of SARS-CoV-2 and its variants

J Arizti-Sanz, AD Bradley, YB Zhang… - Nature biomedical …, 2022 - nature.com
The widespread transmission and evolution of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) call for rapid nucleic acid diagnostics that are easy to use …

Microfluidic space coding for multiplexed nucleic acid detection via CRISPR-Cas12a and recombinase polymerase amplification

Z Xu, D Chen, T Li, J Yan, J Zhu, T He, R Hu… - Nature …, 2022 - nature.com
Fast, inexpensive, and multiplexed detection of multiple nucleic acids is of great importance
to human health, yet it still represents a significant challenge. Herein, we propose a nucleic …

Two years into the COVID-19 pandemic: lessons learned

SJR da Silva, JCF do Nascimento… - ACS infectious …, 2022 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …

Programmable CRISPR-Cas9 microneedle patch for long-term capture and real-time monitoring of universal cell-free DNA

B Yang, J Kong, X Fang - Nature communications, 2022 - nature.com
Recent advances in biointerfaces have led to the development of wearable devices that can
provide insights into personal health. As wearable modules, microneedles can extract …

CRISPR‐Cas‐based detection for food safety problems: Current status, challenges, and opportunities

Y Li, S Man, S Ye, G Liu, L Ma - Comprehensive Reviews in …, 2022 - Wiley Online Library
Food safety is one of the biggest public issues occurring around the world. Microbiological,
chemical, and physical hazards can lead to food safety issues, which may occur at all stages …

Enhancing CRISPR-Cas-mediated detection of nucleic acid and non-nucleic acid targets using enzyme-labeled reporters

D Samanta, SB Ebrahimi, N Ramani… - Journal of the American …, 2022 - ACS Publications
We introduce a new method to generate an amplified signal in CRISPR-Cas-based
detection. Target recognition activates a CRISPR-Cas complex, leading to catalytic cleavage …