Whole-genome sequencing of bacteria has recently emerged as a cost-effective and
convenient approach for addressing many microbiological questions. Here, we review the …

Drug-resistant tuberculosis (DR-TB), including multi-and extensively drug-resistant TB, is
posing a significant challenge to effective treatment and TB control worldwide. New progress …

Assays for the molecular detection of nucleic acids are typically constrained by the level of
multiplexing (this is the case for the quantitative polymerase chain reaction (qPCR) and for …

Background The detection of mutations in the gyrA and gyrB genes in the Mycobacterium
tuberculosis genome that have been demonstrated to confer phenotypic resistance to …

Bacterial persisters are a subpopulation of cells that can tolerate lethal concentrations of
antibiotics. However, the possibility of the emergence of genetically resistant mutants from …

Drug-resistant tuberculosis (TB) poses a significant challenge to the successful treatment
and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of …

Objectives Mutations in the gyrase genes cause fluoroquinolone resistance in
Mycobacterium tuberculosis. However, the predictive value of these markers for clinical …

In order to correlate the mutations inside the entire gyrA and gyrB genes with the level of
resistance to ofloxacin (OFX) and moxifloxacin (MFX) in isolates of multidrug-resistant …

Whole genome sequencing (WGS) of Mycobacterium tuberculosis has been constructive in
understanding its evolution, genetic diversity and the mechanisms involved in drug …

China is one of the countries with the highest burdens of multidrug-resistant (MDR) and
fluoroquinolone (FQ)-resistant tuberculosis (TB) globally. Nevertheless, knowledge about …