The structure and function of the Na, K-ATPase isoforms in health and disease
The sodium and potassium gradients across the plasma membrane are used by animal cells
for numerous processes, and the range of demands requires that the responsible ion pump …
for numerous processes, and the range of demands requires that the responsible ion pump …
Na, K-ATPase regulation in skeletal muscle
S Pirkmajer, AV Chibalin - American Journal of Physiology …, 2016 - journals.physiology.org
Skeletal muscle contains one of the largest and the most dynamic pools of Na, K-ATPase
(NKA) in the body. Under resting conditions, NKA in skeletal muscle operates at only a …
(NKA) in the body. Under resting conditions, NKA in skeletal muscle operates at only a …
Physico-pathologic mechanisms involved in neurodegeneration: misfolded protein-plasma membrane interactions
Several neurodegenerative disorders, such as Alzheimer's and Parkinson's disease, are
characterized by prominent loss of synapses and neurons associated with the presence of …
characterized by prominent loss of synapses and neurons associated with the presence of …
GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump
G Schneditz, JE Elias, E Pagano, M Zaeem Cader… - Science …, 2019 - science.org
The sodium potassium pump (Na/K-ATPase) ensures the electrochemical gradient of a cell
through an energy-dependent process that consumes about one-third of regenerated ATP …
through an energy-dependent process that consumes about one-third of regenerated ATP …
The Na+/K+-ATPase: A potential therapeutic target in cardiometabolic diseases
Cardiometabolic diseases (CMD) are a direct consequence of modern living and contribute
to the development of multisystem diseases such as cardiovascular diseases and diabetes …
to the development of multisystem diseases such as cardiovascular diseases and diabetes …
The vascular Na, K-ATPase: clinical implications in stroke, migraine, and hypertension
In the vascular wall, the Na, K-ATPase plays an important role in the control of arterial tone.
Through cSrc signaling, it contributes to the modulation of Ca2+ sensitivity in vascular …
Through cSrc signaling, it contributes to the modulation of Ca2+ sensitivity in vascular …
Cell biology and dynamics of Neuronal Na+/K+-ATPase in health and diseases
Abstract Neuronal Na+/K+-ATPase is responsible for the maintenance of ionic gradient
across plasma membrane. In doing so, in a healthy brain, Na+/K+-ATPase activity accounts …
across plasma membrane. In doing so, in a healthy brain, Na+/K+-ATPase activity accounts …
Endogenous digitalis-like factors as a key molecule in the pathophysiology of pregnancy-induced hypertension and a potential therapeutic target in preeclampsia
MW Socha, J Chmielewski, M Pietrus… - International Journal of …, 2023 - mdpi.com
Preeclampsia (PE), the most severe presentation of hypertensive disorders of pregnancy, is
the major cause of morbidity and mortality linked to pregnancy, affecting both mother and …
the major cause of morbidity and mortality linked to pregnancy, affecting both mother and …
The sodium pump and digitalis drugs: Dogmas and fallacies
A Askari - Pharmacology Research & Perspectives, 2019 - Wiley Online Library
The sodium pump (Na/K‐ATPase) is a plasma membrane enzyme that transports Na+ and
K+ against their physiological gradients in most eukaryotic cells. Besides pum** ions, the …
K+ against their physiological gradients in most eukaryotic cells. Besides pum** ions, the …
The relevance of α-KLOTHO to the central nervous system: some key questions
Abstract α-Klotho is well described as an anti-aging protein, with critical roles in kidney
function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum. α …
function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum. α …