Modulation of the biochemical composition of the tumour microenvironment is a new frontier
of cancer therapy. Several immunosuppressive mechanisms operate in the milieu of most …

While intracellular adenosine triphosphate (ATP) occupies a key position in the bioenergetic
metabolism of all the cellular compartments that form the tumor microenvironment (TME) …

Extracellular ATP (eATP) is an ancient 'danger signal'used by eukaryotes to detect cellular
damage. In mice and humans, the release of eATP during inflammation or injury stimulates …

Extracellular nucleotides (eg, ATP, ADP, UTP, UDP) released by inflammatory cells interact
with specific purinergic P2 type receptors to modulate their recruitment and activation. The …

ATP, NAD+, and nucleic acids are abundant purines that, in addition to having critical
intracellular functions, have evolved extracellular roles as danger signals released in …

ATP and its receptor P2RX7 exert a pivotal effect on antitumor immunity during
chemotherapy-induced immunogenic cell death (ICD). Here, we demonstrated that TNFα …

The ability of focal radiotherapy to promote priming of tumor-specific CD8+ T cells and
increase responses to immunotherapy is dependent on infiltration of the tumor by Batf3 …

Migratory dendritic cells (migDCs) continuously patrol tissues and are activated by injury
and inflammation. Extracellular adenosine triphosphate (ATP) is released by damaged cells …

Dendritic cells (DCs) are a heterogeneous population of antigen-presenting cells that act to
bridge innate and adaptive immunity. DCs are critical in mounting effective immune …

Immunogenic cell death (ICD) is a stress-driven form of regulated cell death (RCD) in which
dying tumor cells' specific signaling pathways are activated to release damage-associated …