Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

[HTML][HTML] Appraisal for the potential of viral and nonviral vectors in gene therapy: A review

MH Butt, M Zaman, A Ahmad, R Khan, TH Mallhi… - Genes, 2022 - mdpi.com
Over the past few decades, gene therapy has gained immense importance in medical
research as a promising treatment strategy for diseases such as cancer, AIDS, Alzheimer's …

Biomedical polymers: synthesis, properties, and applications

WH Chen, QW Chen, Q Chen, C Cui, S Duan… - Science China …, 2022 - Springer
Biomedical polymers have been extensively developed for promising applications in a lot of
biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis …

Nonviral cancer gene therapy: delivery cascade and vector nanoproperty integration

Z Zhou, X Liu, D Zhu, Y Wang, Z Zhang, X Zhou… - Advanced drug delivery …, 2017 - Elsevier
Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …

Electrostatic Attractive Self‐Delivery of siRNA and Light‐Induced Self‐Escape for Synergistic Gene Therapy

Y Yang, H Ning, T **a, J Du, W Sun, J Fan… - Advanced …, 2023 - Wiley Online Library
Small interfering RNA (siRNA) holds immense promise for suppressing gene expression
and treating various life‐threatening diseases, including cancer. However, efficient delivery …

Biodegradable polymers for gene-delivery applications

CK Chen, PK Huang, WC Law, CH Chu… - International journal …, 2020 - Taylor & Francis
Gene-based therapies have emerged as a new modality for combating a myriad of currently
incurable diseases. However, the fragile nature of gene therapeutics has significantly …

Tumor acidity-sensitive polymeric vector for active targeted siRNA delivery

CY Sun, S Shen, CF Xu, HJ Li, Y Liu… - Journal of the …, 2015 - ACS Publications
Although surface PEGylation of siRNA vectors is effective for preventing protein adsorption
and thereby helps these vectors to evade the reticuloendothelial system (RES) in vivo, it also …

A crosslinked nucleic acid nanogel for effective siRNA delivery and antitumor therapy

F Ding, Q Mou, Y Ma, G Pan, Y Guo… - Angewandte Chemie …, 2018 - Wiley Online Library
Functional siRNAs are employed as cross‐linkers to direct the self‐assembly of DNA‐
grafted polycaprolactone (DNA‐g‐PCL) brushes to form spherical and nanosized hydrogels …

Endogenous pH-responsive nanoparticles with programmable size changes for targeted tumor therapy and imaging applications

W Wu, L Luo, Y Wang, Q Wu, HB Dai, JS Li… - …, 2018 - pmc.ncbi.nlm.nih.gov
Nanotechnology-based antitumor drug delivery systems, known as nanocarriers, have
demonstrated their efficacy in recent years. Typically, the size of the nanocarriers is around …

Nanomaterials for cancer precision medicine

Y Wang, S Sun, Z Zhang, D Shi - Advanced materials, 2018 - Wiley Online Library
Medical science has recently advanced to the point where diagnosis and therapeutics can
be carried out with high precision, even at the molecular level. A new field of “precision …