In distributive phosphorylation catalytic constants enable non-trivial dynamics

C Conradi, M Mincheva - Journal of Mathematical Biology, 2024‏ - Springer
Ordered distributive double phosphorylation is a recurrent motif in intracellular signaling and
control. It is either sequential (where the site phosphorylated last is dephosphorylated first) …

[PDF][PDF] A necessary condition for non-monotonic dose response, with an application to a kinetic proofreading model

P Yu, ED Sontag - Proc. 2024 63rd IEEE Conference on …, 2024‏ - css.paperplaza.net
Steady state nonmonotonic (“biphasic”) dose responses are often observed in experimental
biology, which raises the control-theoretic question of identifying which possible …

A unified approach to dissecting biphasic responses in cell signaling

V Ramesh, J Krishnan - Elife, 2023‏ - elifesciences.org
Biphasic responses are encountered at all levels in biological systems. At the cellular level,
biphasic dose-responses are widely encountered in cell signaling and post-translational …

A unified approach to dissecting biphasic responses in cell signaling

R Vaidhiswaran, J Krishnan - eLife, 2023‏ - search.proquest.com
Biphasic responses are encountered at all levels in biological systems. At the cellular level,
biphasic dose-responses are widely encountered in cell signaling and post-translational …

Biphasic responses in cell signalling: A unified approach

V Ramesh, J Krishnan - bioRxiv, 2023‏ - biorxiv.org
Biphasic responses are encountered at all levels in biological systems. At the cellular level,
biphasic dose-responses are widely encountered in cell signalling and post-translational …