Altered lipid metabolism is among the most prominent metabolic alterations in cancer.
Enhanced synthesis or uptake of lipids contributes to rapid cancer cell growth and tumor …

Cancer cell possesses numerous adaptations to resist the immune system response and
chemotherapy. One of the most significant properties of the neoplastic cells is the altered …

Activation of ferroptosis, a recently described mechanism of regulated cell death,
dramatically inhibits growth of ovarian cancer cells. Given the importance of lipid metabolism …

Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular
process that converts nutrients into metabolic intermediates for membrane biosynthesis …

Cancer cells are often exposed to a metabolically challenging environment with scarce
availability of oxygen and nutrients. This metabolic stress leads to changes in the balance …

Introduction Lipidomics focuses on the in-depth analysis of lipids, which are crucial
macromolecules involved in a wide range of metabolic pathways. The increased …

Most tumours have an aberrantly activated lipid metabolism, that enables them to
synthesize, elongate and desaturate fatty acids to support proliferation. However, only …

An increased rate of lipid synthesis in cancerous tissues has long been recognised as an
important aspect of the rewired metabolism of transformed cells. However, the contribution of …

A distinctive feature of cancer cells of various origins involves alterations of the composition
of lipids, with significant enrichment in monounsaturated fatty acids. These molecules, in …

Cancer cell growth requires fatty acids to replicate cellular membranes. The kinase Akt is
known to up-regulate fatty acid synthesis and desaturation, which is carried out by the …