G-protein-coupled receptors (GPCRs) constitute a prominent superfamily in humans and are
categorized into six classes (A–F) that play indispensable roles in cellular communication …

G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide
array of physiological processes and responses, such as sensory perception (eg, vision …

Individual free fatty acids (FAs) play important roles in metabolic homeostasis, many through
engagement with more than 40G protein–coupled receptors. Searching for receptors to …

Trace-amine-associated receptors (TAARs), a group of biogenic amine receptors, have
essential roles in neurological and metabolic homeostasis. They recognize diverse …

G-protein-coupled receptors (GPCRs) are a class of integral membrane proteins that detect
environmental cues and trigger cellular responses. Deciphering the functional states of …

The complement system plays an important role in the innate immune response to invading
pathogens. The complement fragment C5a is one of its important effector components and …

Lysosomes have crucial roles in regulating eukaryotic metabolism and cell growth by acting
as signalling platforms to sense and respond to changes in nutrient and energy availability …

Adhesion G-protein-coupled receptors (aGPCRs) bear notable similarity to Notch proteins, a
class of surface receptors poised for mechano-proteolytic activation,–, including an …

Adhesion G-protein-coupled receptors (aGPCRs) play key roles in a diversity of
physiologies. A hallmark of aGPCR activation is the removal of the inhibitory GAIN domain …

Adhesion G protein-coupled receptors (aGPCRs) have extracellular regions (ECRs)
containing GPCR autoproteolysis-inducing (GAIN) domains. The GAIN domain enables the …