For centuries, gold had been considered a precious, purely decorative inert metal. It was not
until 1986 that Ito and Hayashi described the first application of gold (I) in homogeneous …

This review describes the gold-catalyzed reactions of specially activated alkynes, allenes,
and alkenes. Such species are characterized by the presence of either electron-donating or …

The catalyst-directed divergent synthesis, commonly termed as “divergent catalysis”, has
emerged as a promising technique as it allows chartering of structurally distinct products …

Spiroindolines and spiroindoles are an important class of spirocyclic compounds present in
a wide range of pharmaceuticals and biologically important natural alkaloids. Various …

Dearomatization strategies in a multicomponent fashion often result in complex heterocyclic
frameworks, which have attracted the attention of chemists due to their natural product-like …

The Ugi-4CR is by far one of the most successful multicomponent reactions leading to high
structural diversity and molecular complexity. However, the reaction mostly affords a linear …

Spirocyclic indole derivatives are fascinating tridimensional molecular scaffolds from both a
synthetic and a biological point of view. Among the many strategies developed to access …

For two decades, diversity-oriented synthesis (DOS) has facilitated the assembly of small-
molecule libraries comprising a variety of complex molecular architectures. Here, we …

Polycyclic scaffolds are omnipresent in natural products and drugs, and the synthetic
strategies and methods toward construction of these scaffolds are of particular importance …

Indoles are some of the most versatile and common nitrogen-based heterocyclic scaffolds
and are frequently used in the synthesis of various organic compounds. Indole based …