The vestibular system is a critical part of the human balance system, malfunction of this
system will lead to balance disorders, such as vertigo. Mammalian vestibular hair cells, the …

Better understanding the mechanism of cisplatin-induced ototoxicity is of great significance
for clinical prevention and treatment of cisplatin-related hearing loss. However, the …

Abstract N6-methyladenosine (m6A) has been recognized as a common type of post-
transcriptional epigenetic modification. m6A modification and YTHDF1, one of its reader …

Cochlear implantation (CI) is the major treatment for severe sensorineural hearing loss.
However, the fibrotic tissue forming around the electrodes reduces the treatment …

Background Phosphatidylserine is translocated to the inner leaflet of the phospholipid
bilayer membrane by the flippase function of type IV P-tape ATPase (P4-ATPase), which is …

The Kölliker's organ is a transient cellular cluster structure in the development of the
mammalian cochlea. It gradually degenerates from embryonic columnar cells to cuboidal …

Mutations in a number of genes encoding mitochondrial aminoacyl-tRNA synthetases lead
to non-syndromic and/or syndromic sensorineural hearing loss in humans, while their …

Hair cells play key roles in hearing and balance, and hair cell loss would result in hearing
loss or vestibular dysfunction. Cellular and molecular research in hair cell biology provides …

Aims The present study was aimed to explore the possible mechanism (s) underlying the
action of cisplatin on auditory cells of mice in vitro, with special attention given to the …

Objectives Age-related hearing loss (ARHL) is much more prevalent with age, affecting not
only peripheral but central auditory system. We have previously established an aging model …