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Structural and functional diversity of type IV secretion systems
Considerable progress has been made in recent years in the structural and molecular
biology of type IV secretion systems in Gram-negative bacteria. The latest advances have …
biology of type IV secretion systems in Gram-negative bacteria. The latest advances have …
Molecular architecture of bacterial type IV secretion systems
Bacterial type IV secretion systems (T4SSs) are a versatile group of nanomachines that can
horizontally transfer DNA through conjugation and deliver effector proteins into a wide range …
horizontally transfer DNA through conjugation and deliver effector proteins into a wide range …
Cryo-EM structure of a conjugative type IV secretion system suggests a molecular switch regulating pilus biogenesis
Conjugative type IV secretion systems (T4SS) mediate bacterial conjugation, a process that
enables the unidirectional exchange of genetic materials between a donor and a recipient …
enables the unidirectional exchange of genetic materials between a donor and a recipient …
The F-pilus biomechanical adaptability accelerates conjugative dissemination of antimicrobial resistance and biofilm formation
Conjugation is used by bacteria to propagate antimicrobial resistance (AMR) in the
environment. Central to this process are widespread conjugative F-pili that establish the …
environment. Central to this process are widespread conjugative F-pili that establish the …
The Legionella pneumophila Dot/Icm type IV secretion system and its effectors
DC Lockwood, H Amin, TRD Costa… - …, 2022 - microbiologyresearch.org
To prevail in the interaction with eukaryotic hosts, many bacterial pathogens use protein
secretion systems to release virulence factors at the host–pathogen interface and/or deliver …
secretion systems to release virulence factors at the host–pathogen interface and/or deliver …
DNA transport through the dynamic type IV secretion system
The versatile type IV secretion system (T4SS) nanomachine plays a pivotal role in bacterial
pathogenesis and the propagation of antibiotic resistance determinants throughout microbial …
pathogenesis and the propagation of antibiotic resistance determinants throughout microbial …
Chimeric systems composed of swapped Tra subunits between distantly-related F plasmids reveal striking plasticity among type IV secretion machines
Bacterial type IV secretion systems (T4SSs) are a versatile family of macromolecular
translocators, collectively able to recruit diverse DNA and protein substrates and deliver …
translocators, collectively able to recruit diverse DNA and protein substrates and deliver …
Contributions of F‐specific subunits to the F plasmid‐encoded type IV secretion system and F pilus
F plasmids circulate widely among the Enterobacteriaceae through encoded type IV
secretion systems (T4SSFs). Assembly of T4SSFs and associated F pili requires 10 …
secretion systems (T4SSFs). Assembly of T4SSFs and associated F pili requires 10 …
Target recognition by RNase E RNA-binding domain AR2 drives sRNA decay in the absence of PNPase
The C-terminal domain (CTD) of the major endoribonuclease RNase E not only serves as a
scaffold for the central RNA decay machinery in gram-negative bacteria but also mediates …
scaffold for the central RNA decay machinery in gram-negative bacteria but also mediates …
Role of the CagY antenna projection in Helicobacter pylori Cag type IV secretion system activity
SC Tran, MS McClain, TL Cover - Infection and Immunity, 2023 - journals.asm.org
Helicobacter pylori strains containing the cag pathogenicity island (PAI) are associated with
the development of gastric adenocarcinoma and peptic ulcer disease. The cag PAI encodes …
the development of gastric adenocarcinoma and peptic ulcer disease. The cag PAI encodes …