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Fiber-type shifting in sarcopenia of old age: proteomic profiling of the contractile apparatus of skeletal muscles
The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …
Emerging therapeutic strategies in sarcopenia: an updated review on pathogenesis and treatment advances
Sarcopenia is a prevalent degenerative skeletal muscle condition in the elderly population,
posing a tremendous burden on diseased individuals and healthcare systems worldwide …
posing a tremendous burden on diseased individuals and healthcare systems worldwide …
The current landscape of pharmacotherapies for sarcopenia
G Bahat, S Ozkok - Drugs & aging, 2024 - Springer
Sarcopenia is a skeletal muscle disorder characterized by progressive and generalized
decline in muscle mass and function. Although it is mostly known as an age-related disorder …
decline in muscle mass and function. Although it is mostly known as an age-related disorder …
Advances in the study of extracellular vesicles for bone regeneration
Y Jiao, Y Liu, J Du, J Xu, Z Luo, Y Liu… - International Journal of …, 2024 - mdpi.com
Promoting the efficiency of bone regeneration in bone loss diseases is a significant clinical
challenge. Traditional therapies often fail to achieve better therapeutic outcomes and shorter …
challenge. Traditional therapies often fail to achieve better therapeutic outcomes and shorter …
Ginsenoside Rh4 delays skeletal muscle aging through SIRT1 pathway
A Zhu, Z Duan, Y Chen, C Zhu, D Fan - Phytomedicine, 2023 - Elsevier
Background The aging of skeletal muscle is the leading cause of physical disability in older
adults, currently effective treatment methods are lacking. Ginsenoside Rh4, an active …
adults, currently effective treatment methods are lacking. Ginsenoside Rh4, an active …
Bone engineering scaffolds with exosomes: a promising strategy for bone defects repair
M Zhang, Y Li, T Feng, R Li, Z Wang… - … in Bioengineering and …, 2022 - frontiersin.org
The treatment of bone defects is still an intractable clinical problem, despite the fact that
numerous treatments are currently available. In recent decades, bone engineering scaffolds …
numerous treatments are currently available. In recent decades, bone engineering scaffolds …
[HTML][HTML] Advancements in Drug Delivery Systems for the Treatment of Sarcopenia: An Updated Overview
Since sarcopenia is a progressive condition that leads to decreased muscle mass and
function, especially in elderly people, it is a public health problem that requires attention …
function, especially in elderly people, it is a public health problem that requires attention …
[HTML][HTML] Computational identification of dithymoquinone as a potential inhibitor of myostatin and regulator of muscle mass
The skeletal muscle (SM) is the largest organ in the body and has tremendous regenerative
power due to its myogenic stem cell population. Myostatin (MSTN), a protein produced by …
power due to its myogenic stem cell population. Myostatin (MSTN), a protein produced by …
Bioactive glass and silica particles for skeletal and cardiac muscle tissue regeneration
When skeletal and cardiac tissues are damaged, surgical approaches are not always
successful and tissue regeneration approaches are investigated. Reports in the literature …
successful and tissue regeneration approaches are investigated. Reports in the literature …
Systematic Review of Genetic Substrate Reduction Therapy in Lysosomal Storage Diseases: Opportunities, Challenges and Delivery Systems
M Beraza-Millor, J Rodríguez-Castejón… - BioDrugs, 2024 - Springer
Background Genetic substrate reduction therapy (gSRT), which involves the use of nucleic
acids to downregulate the genes involved in the biosynthesis of storage substances, has …
acids to downregulate the genes involved in the biosynthesis of storage substances, has …