Fiber-type shifting in sarcopenia of old age: proteomic profiling of the contractile apparatus of skeletal muscles

P Dowling, S Gargan, D Swandulla… - International Journal of …, 2023 - mdpi.com
The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

Emerging therapeutic strategies in sarcopenia: an updated review on pathogenesis and treatment advances

A Najm, AG Niculescu, AM Grumezescu… - International Journal of …, 2024 - mdpi.com
Sarcopenia is a prevalent degenerative skeletal muscle condition in the elderly population,
posing a tremendous burden on diseased individuals and healthcare systems worldwide …

The current landscape of pharmacotherapies for sarcopenia

G Bahat, S Ozkok - Drugs & aging, 2024 - Springer
Sarcopenia is a skeletal muscle disorder characterized by progressive and generalized
decline in muscle mass and function. Although it is mostly known as an age-related disorder …

Advances in the study of extracellular vesicles for bone regeneration

Y Jiao, Y Liu, J Du, J Xu, Z Luo, Y Liu… - International Journal of …, 2024 - mdpi.com
Promoting the efficiency of bone regeneration in bone loss diseases is a significant clinical
challenge. Traditional therapies often fail to achieve better therapeutic outcomes and shorter …

Ginsenoside Rh4 delays skeletal muscle aging through SIRT1 pathway

A Zhu, Z Duan, Y Chen, C Zhu, D Fan - Phytomedicine, 2023 - Elsevier
Background The aging of skeletal muscle is the leading cause of physical disability in older
adults, currently effective treatment methods are lacking. Ginsenoside Rh4, an active …

Bone engineering scaffolds with exosomes: a promising strategy for bone defects repair

M Zhang, Y Li, T Feng, R Li, Z Wang… - … in Bioengineering and …, 2022 - frontiersin.org
The treatment of bone defects is still an intractable clinical problem, despite the fact that
numerous treatments are currently available. In recent decades, bone engineering scaffolds …

[HTML][HTML] Advancements in Drug Delivery Systems for the Treatment of Sarcopenia: An Updated Overview

A Najm, ET Moldoveanu, AG Niculescu… - International Journal of …, 2024 - mdpi.com
Since sarcopenia is a progressive condition that leads to decreased muscle mass and
function, especially in elderly people, it is a public health problem that requires attention …

[HTML][HTML] Computational identification of dithymoquinone as a potential inhibitor of myostatin and regulator of muscle mass

SS Ahmad, K Ahmad, EJ Lee, S Shaikh, I Choi - Molecules, 2021 - mdpi.com
The skeletal muscle (SM) is the largest organ in the body and has tremendous regenerative
power due to its myogenic stem cell population. Myostatin (MSTN), a protein produced by …

Bioactive glass and silica particles for skeletal and cardiac muscle tissue regeneration

D Ege, HH Lu, AR Boccaccini - Tissue Engineering Part B: Reviews, 2024 - liebertpub.com
When skeletal and cardiac tissues are damaged, surgical approaches are not always
successful and tissue regeneration approaches are investigated. Reports in the literature …

Systematic Review of Genetic Substrate Reduction Therapy in Lysosomal Storage Diseases: Opportunities, Challenges and Delivery Systems

M Beraza-Millor, J Rodríguez-Castejón… - BioDrugs, 2024 - Springer
Background Genetic substrate reduction therapy (gSRT), which involves the use of nucleic
acids to downregulate the genes involved in the biosynthesis of storage substances, has …