Deciphering the multi-scale, quantitative cis-regulatory code
S Kim, J Wysocka - Molecular cell, 2023 - cell.com
Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …
Machine learning meets omics: applications and perspectives
The innovation of biotechnologies has allowed the accumulation of omics data at an
alarming rate, thus introducing the era of 'big data'. Extracting inherent valuable knowledge …
alarming rate, thus introducing the era of 'big data'. Extracting inherent valuable knowledge …
Affinity-optimizing enhancer variants disrupt development
Enhancers control the location and timing of gene expression and contain the majority of
variants associated with disease,–. The ZRS is arguably the most well-studied vertebrate …
variants associated with disease,–. The ZRS is arguably the most well-studied vertebrate …
The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening
A mechanistic connection between aging and development is largely unexplored. Through
profiling age-related chromatin and transcriptional changes across 22 murine cell types …
profiling age-related chromatin and transcriptional changes across 22 murine cell types …
EGR1 is a gatekeeper of inflammatory enhancers in human macrophages
M Trizzino, A Zucco, S Deliard, F Wang, E Barbieri… - Science …, 2021 - science.org
Monocytes and monocyte-derived macrophages originate through a multistep differentiation
process. First, hematopoietic stem cells generate lineage-restricted progenitors that …
process. First, hematopoietic stem cells generate lineage-restricted progenitors that …
Single-cell epigenomics and functional fine-map** of atherosclerosis GWAS loci
T Örd, K Õunap, LK Stolze, R Aherrahrou… - Circulation …, 2021 - Am Heart Assoc
Rationale: Genome-wide association studies have identified hundreds of loci associated
with coronary artery disease (CAD). Many of these loci are enriched in cisregulatory …
with coronary artery disease (CAD). Many of these loci are enriched in cisregulatory …
A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response
A widespread strategy employed by pathogens to establish infection is to inhibit host-cell
protein synthesis. Legionella pneumophila, an intracellular bacterial pathogen and the …
protein synthesis. Legionella pneumophila, an intracellular bacterial pathogen and the …
Dichotomous engagement of HDAC3 activity governs inflammatory responses
The histone deacetylases (HDACs) are a superfamily of chromatin-modifying enzymes that
silence transcription through the modification of histones. Among them, HDAC3 is unique in …
silence transcription through the modification of histones. Among them, HDAC3 is unique in …
[HTML][HTML] Exploiting dynamic enhancer landscapes to decode macrophage and microglia phenotypes in health and disease
The development and functional potential of metazoan cells is dependent on combinatorial
roles of transcriptional enhancers and promoters. Macrophages provide exceptionally …
roles of transcriptional enhancers and promoters. Macrophages provide exceptionally …
REV-ERB nuclear receptors in the suprachiasmatic nucleus control circadian period and restrict diet-induced obesity
Circadian disruption, as occurs in shift work, is associated with metabolic diseases often
attributed to a discordance between internal clocks and environmental timekeepers. REV …
attributed to a discordance between internal clocks and environmental timekeepers. REV …