Ins and outs of the TCA cycle: the central role of anaplerosis
M Inigo, S Deja, SC Burgess - Annual review of nutrition, 2021 - annualreviews.org
The reactions of the tricarboxylic acid (TCA) cycle allow the controlled combustion of fat and
carbohydrate. In principle, TCA cycle intermediates are regenerated on every turn and can …
carbohydrate. In principle, TCA cycle intermediates are regenerated on every turn and can …
A guide to 13C metabolic flux analysis for the cancer biologist
MR Antoniewicz - Experimental & molecular medicine, 2018 - nature.com
Cancer metabolism is significantly altered from normal cellular metabolism allowing cancer
cells to adapt to changing microenvironments and maintain high rates of proliferation. In the …
cells to adapt to changing microenvironments and maintain high rates of proliferation. In the …
Carbon source availability drives nutrient utilization in CD8+ T cells
How environmental nutrient availability impacts T cell metabolism and function remains
poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) …
poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) …
Switching to the cyclic pentose phosphate pathway powers the oxidative burst in activated neutrophils
Neutrophils are cells at the frontline of innate immunity that can quickly activate effector
functions to eliminate pathogens upon stimulation. However, little is known about the …
functions to eliminate pathogens upon stimulation. However, little is known about the …
Daylength variation affects growth, photosynthesis, leaf metabolism, partitioning, and metabolic fluxes
Y Xu, AA Koroma, SE Weise, X Fu, TD Sharkey… - Plant …, 2024 - academic.oup.com
Daylength, a seasonal and latitudinal variable, exerts a substantial impact on plant growth.
However, the relationship between daylength and growth is nonproportional, suggesting the …
However, the relationship between daylength and growth is nonproportional, suggesting the …
Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer
SLC7A11-mediated cystine uptake is critical for maintaining redox balance and cell survival.
Here we show that this comes at a significant cost for cancer cells with high levels of …
Here we show that this comes at a significant cost for cancer cells with high levels of …
Reimport of carbon from cytosolic and vacuolar sugar pools into the Calvin–Benson cycle explains photosynthesis labeling anomalies
When isotopes of carbon are fed to photosynthesizing leaves, metabolites of the Calvin–
Benson cycle (CBC) are rapidly labeled initially, but then the rate of labeling slows …
Benson cycle (CBC) are rapidly labeled initially, but then the rate of labeling slows …
Serine restriction alters sphingolipid diversity to constrain tumour growth
Serine, glycine and other nonessential amino acids are critical for tumour progression, and
strategies to limit their availability are emerging as potential therapies for cancer,–. However …
strategies to limit their availability are emerging as potential therapies for cancer,–. However …
Integrated flux and pool size analysis in plant central metabolism reveals unique roles of glycine and serine during photorespiration
Photorespiration is an essential process juxtaposed between plant carbon and nitrogen
metabolism that responds to dynamic environments. Photorespiration recycles inhibitory …
metabolism that responds to dynamic environments. Photorespiration recycles inhibitory …
Acetate reprograms gut microbiota during alcohol consumption
Liver damage due to chronic alcohol use is among the most prevalent liver diseases.
Alcohol consumption frequency is a strong factor of microbiota variance. Here we use …
Alcohol consumption frequency is a strong factor of microbiota variance. Here we use …