The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

A new class of noncoding RNAs, tsRNAs are not only abundant in humans but also have
high tissue specificity. Recently, an increasing number of studies have explored the …

As the adaptor that decodes mRNA sequence into protein, the basic aspects of tRNA
structure and function are central to all studies of biology. Yet the complexities of their …

Radiofrequency heat ablation is an ideal radical treatment for hepatocellular carcinoma
(HCC). However, insufficient radiofrequency ablation (IRFA) could lead to high recurrence of …

Transfer RNAs (tRNAs) are the most highly modified cellular RNAs, both with respect to the
proportion of nucleotides that are modified within the tRNA sequence and with respect to the …

Nonsense mutations change an amino acid codon to a premature termination codon (PTC)
generally through a single‐nucleotide substitution. The generation of a PTC results in a …

Significance: Oxidative stress refers to excessive intracellular levels of reactive oxygen
species (ROS) due to an imbalance between ROS production and the antioxidant defense …

The pool of transfer RNA (tRNA) molecules in cells allows the ribosome to decode genetic
information. This repertoire of molecular decoders is positioned in the crossroad of the …

Through its role in intron cleavage, tRNA splicing endonuclease (TSEN) plays a critical
function in the maturation of intron-containing pre-tRNAs. The catalytic mechanism and core …

Perfectly accurate translation of mRNA into protein is not a prerequisite for life. Resulting
from errors in protein synthesis, mistranslation occurs in all cells, including human cells. The …