The potential of in vitro neuronal networks cultured on micro electrode arrays for biomedical research

M Cerina, MC Piastra, M Frega - Progress in Biomedical …, 2023 - iopscience.iop.org
In vitro neuronal models have become an important tool to study healthy and diseased
neuronal circuits. The growing interest of neuroscientists to explore the dynamics of …

Advances in nano neuroscience: From nanomaterials to nanotools

NP Pampaloni, M Giugliano, D Scaini… - Frontiers in …, 2019 - frontiersin.org
During the last decades, neuroscientists have increasingly exploited a variety of artificial, de-
novo synthesized materials with controlled nano-sized features. For instance, a renewed …

3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics

H Shin, S Jeong, JH Lee, W Sun, N Choi… - Nature communications, 2021 - nature.com
Investigation of neural circuit dynamics is crucial for deciphering the functional connections
among regions of the brain and understanding the mechanism of brain dysfunction. Despite …

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

DJ Bakkum, U Frey, M Radivojevic, TL Russell… - Nature …, 2013 - nature.com
Axons are traditionally considered stable transmission cables, but evidence of the regulation
of action potential propagation demonstrates that axons may have more important roles …

Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses

C Gottschling, D Wegrzyn, B Denecke, A Faissner - Scientific reports, 2019 - nature.com
The synaptic transmission in the mammalian brain is not limited to the interplay between the
pre-and the postsynapse of neurons, but involves also astrocytes as well as extracellular …

Optogenetic feedback control of neural activity

JP Newman, M Fong, DC Millard, CJ Whitmire… - Elife, 2015 - elifesciences.org
Optogenetic techniques enable precise excitation and inhibition of firing in specified
neuronal populations and artifact-free recording of firing activity. Several studies have …

Self-organization of in vitro neuronal assemblies drives to complex network topology

PC Antonello, TF Varley, J Beggs, M Porcionatto… - Elife, 2022 - elifesciences.org
Activity-dependent self-organization plays an important role in the formation of specific and
stereotyped connectivity patterns in neural circuits. By combining neuronal cultures, and …

Parameters for burst detection

DJ Bakkum, M Radivojevic, U Frey, F Franke… - Frontiers in …, 2014 - frontiersin.org
Bursts of action potentials within neurons and throughout networks are believed to serve
roles in how neurons handle and store information, both in vivo and in vitro. Accurate …

Criticality maximizes complexity in neural tissue

NM Timme, NJ Marshall, N Bennett, M Ripp… - Frontiers in …, 2016 - frontiersin.org
The analysis of neural systems leverages tools from many different fields. Drawing on
techniques from the study of critical phenomena in statistical mechanics, several studies …

Modular architecture facilitates noise-driven control of synchrony in neuronal networks

H Yamamoto, FP Spitzner, T Takemuro, V Buendía… - Science …, 2023 - science.org
High-level information processing in the mammalian cortex requires both segregated
processing in specialized circuits and integration across multiple circuits. One possible way …