Pioneer factors are a special class of transcription factor that can associate with compacted
chromatin to facilitate the binding of additional transcription factors. The function of pioneer …

The androgen receptor (AR) signaling axis drives all stages of prostate cancer, including the
lethal, drug-resistant form of the disease termed castration-resistant prostate cancer (CRPC) …

Prostate cancer (PC) progressed to castration resistance (CRPC) is a fatal disease. CRPC
tumors develop resistance to new-generation antiandrogen enzalutamide through lineage …

Forkhead box protein A1 (FOXA1) is a pioneer factor of estrogen receptor α (ER)–chromatin
binding and function, yet its aberration in endocrine-resistant (Endo-R) breast cancer is …

When aberrant, factors critical for organ morphogenesis are also commonly involved in
disease progression. FOXA1 (forkhead box A1), also known as HNF3α (hepatocyte nuclear …

The pioneering factor FOXA1 opens chromatin to facilitate androgen receptor (AR) binding
to prostate-specific genes. How FOXA1 controls the AR cistrome, however, is incompletely …

Prostate cancer (PCa) is the most commonly diagnosed noncutaneous malignancy and
second leading cause of cancer-related deaths in US males. Clinically, locally confined …

The androgen receptor (AR) is a critical therapeutic target in prostate cancer that responds
to antagonists in primary disease, but inevitably becomes reactivated, signaling onset of the …

Chromatin is a well-known obstacle to transcription as it controls DNA accessibility, which
directly impacts the recruitment of the transcriptional machinery. The recent burst of …

FOXA transcription factors are potent, context‐specific mediators of development that hold
specialized functions in hormone‐dependent tissues. Over the last several years, FOXA1 …