A Review of the Important Role of CYP2D6 in Pharmacogenomics
C Taylor, I Crosby, V Yip, P Maguire, M Pirmohamed… - Genes, 2020 - mdpi.com
Cytochrome P450 2D6 (CYP2D6) is a critical pharmacogene involved in the metabolism of~
20% of commonly used drugs across a broad spectrum of medical disciplines including …
20% of commonly used drugs across a broad spectrum of medical disciplines including …
[HTML][HTML] Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation
Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
Extended multiplexing of tandem mass tags (TMT) labeling reveals age and high fat diet specific proteome changes in mouse epididymal adipose tissue
The lack of high-throughput methods to analyze the adipose tissue protein composition
limits our understanding of the protein networks responsible for age and diet related …
limits our understanding of the protein networks responsible for age and diet related …
Targeting BCAA catabolism to treat obesity-associated insulin resistance
M Zhou, J Shao, CY Wu, L Shu, W Dong, Y Liu… - Diabetes, 2019 - Am Diabetes Assoc
Recent studies implicate a strong association between elevated plasma branched-chain
amino acids (BCAAs) and insulin resistance (IR). However, a causal relationship and …
amino acids (BCAAs) and insulin resistance (IR). However, a causal relationship and …
[HTML][HTML] Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease
The genetics of complex disease produce alterations in the molecular interactions of cellular
pathways whose collective effect may become clear through the organized structure of …
pathways whose collective effect may become clear through the organized structure of …
A history of the roles of cytochrome P450 enzymes in the toxicity of drugs
FP Guengerich - Toxicological research, 2021 - Springer
The history of drug metabolism began in the 19th Century and developed slowly. In the mid-
20th Century the relationship between drug metabolism and toxicity became appreciated …
20th Century the relationship between drug metabolism and toxicity became appreciated …
[HTML][HTML] Longitudinal plasma metabolomics of aging and sex
Understanding how metabolites are longitudinally influenced by age and sex could facilitate
the identification of metabolomic profiles and trajectories that indicate disease risk. We …
the identification of metabolomic profiles and trajectories that indicate disease risk. We …
Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance
Cytochrome P450 2B6 (CYP2B6) belongs to the minor drug metabolizing P450s in human
liver. Expression is highly variable both between individuals and within individuals, owing to …
liver. Expression is highly variable both between individuals and within individuals, owing to …
Human cytochrome P450 enzymes
FP Guengerich - Cytochrome P450: structure, mechanism, and …, 2015 - Springer
Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
Complexities of CYP2D6 gene analysis and interpretation
A Gaedigk - International review of psychiatry, 2013 - Taylor & Francis
Abstract Cytochrome P450 2D6 (CYP2D6) plays an important role in the metabolism and
bioactivation of about 25% of clinically used drugs including many antidepressants …
bioactivation of about 25% of clinically used drugs including many antidepressants …