[HTML][HTML] Evaluation of synergism in drug combinations and reference models for future orientations in oncology

D Duarte, N Vale - Current Research in Pharmacology and Drug …, 2022 - Elsevier
Current cancer therapy includes a variety of strategies that can comprise only one type of
treatment or a combination of multiple treatments. Chemotherapy is still the gold standard for …

The inhibitory effects of flavonoids on α-amylase and α-glucosidase

J Zhu, C Chen, B Zhang, Q Huang - Critical Reviews in Food …, 2020 - Taylor & Francis
The objective of this review is to summarize knowledge on the inhibitory effects (IEs) of
flavonoids on α-amylase (αA) and α-glucosidase (αG) relevant to the search of substitutes of …

The combination index (CI< 1) as the definition of synergism and of synergy claims

TC Chou - Synergy, 2018 - Elsevier
The unified theory of the median-effect equation (MEE) of the mass-action law (MAL)
indicates that dose and effect are interchangeable, and all dose-effect curves can be …

Camptothecin and its derivatives: Advancements, mechanisms and clinical potential in cancer therapy

M Kamle, S Pandhi, S Mishra, S Barua, A Kurian… - Medical Oncology, 2024 - Springer
Camptothecin (CPT), an alkaloid isolated from the Camptotheca tree, has demonstrated
significant anticancer properties in a range of malignancies. However, its therapeutic …

Cancer combination therapies with artemisinin-type drugs

T Efferth - Biochemical pharmacology, 2017 - Elsevier
Artemisia annua L. is a Chinese medicinal plant, which is used throughout Asia and Africa
as tea or press juice to treat malaria. The bioactivity of its chemical constituent, artemisinin is …

Carrier-enhanced anticancer efficacy of sunitinib-loaded green tea-based micellar nanocomplex beyond tumor-targeted delivery

N Yongvongsoontorn, JE Chung, SJ Gao, KH Bae… - Acs Nano, 2019 - ACS Publications
Although a few nanomedicines have been approved for clinical use in cancer treatment, that
recognizes improved patient safety through targeted delivery, their improved efficacy over …

Melatonin targets MoIcl1 and works synergistically with fungicide isoprothiolane in rice blast control

R Bi, R Li, Z Xu, H Cai, J Zhao, Y Zhou… - Journal of Pineal …, 2023 - Wiley Online Library
Melatonina natural harmless molecule—displays versatile roles in human health and crop
disease control such as for rice blast. Rice blast, caused by the filamentous fungus …

Synergistic inhibition of isolated flavonoids from Moringa oleifera leaf on α-glucosidase activity

YS Hamed, M Abdin, AM Rayan, HMS Akhtar, X Zeng - Lwt, 2021 - Elsevier
Flavonoids are phenolic substances naturally distributed in plants with potential antidiabetic
activity through the inhibition of α-glucosidase. Therefore, the present study investigated the …

Glycyrrhizic acid enhances the anticancer activity of cisplatin in the human ovarian cancer cell line

F Omidi, S Shahbazi, S Reiisi, S Azhdari… - Toxicology in Vitro, 2023 - Elsevier
This study aimed to investigate the effects of glycyrrhizic acid (GL) on the anticancer activity
of cisplatin in A2780 ovarian cancer cells. Cultured A2780 cells were treated with different …

Cyclin-dependent kinases (CDKs) and the human cytomegalovirus-encoded CDK ortholog pUL97 represent highly attractive targets for synergistic drug combinations

M Wild, F Hahn, N Brückner, M Schütz… - International Journal of …, 2022 - mdpi.com
Human cytomegalovirus (HCMV) is a pathogenic human herpesvirus associated with
serious, potentially life-threatening symptoms in the immunocompromised or immunonaïve …