[HTML][HTML] Evaluation of synergism in drug combinations and reference models for future orientations in oncology
Current cancer therapy includes a variety of strategies that can comprise only one type of
treatment or a combination of multiple treatments. Chemotherapy is still the gold standard for …
treatment or a combination of multiple treatments. Chemotherapy is still the gold standard for …
The inhibitory effects of flavonoids on α-amylase and α-glucosidase
The objective of this review is to summarize knowledge on the inhibitory effects (IEs) of
flavonoids on α-amylase (αA) and α-glucosidase (αG) relevant to the search of substitutes of …
flavonoids on α-amylase (αA) and α-glucosidase (αG) relevant to the search of substitutes of …
The combination index (CI< 1) as the definition of synergism and of synergy claims
TC Chou - Synergy, 2018 - Elsevier
The unified theory of the median-effect equation (MEE) of the mass-action law (MAL)
indicates that dose and effect are interchangeable, and all dose-effect curves can be …
indicates that dose and effect are interchangeable, and all dose-effect curves can be …
Camptothecin and its derivatives: Advancements, mechanisms and clinical potential in cancer therapy
Camptothecin (CPT), an alkaloid isolated from the Camptotheca tree, has demonstrated
significant anticancer properties in a range of malignancies. However, its therapeutic …
significant anticancer properties in a range of malignancies. However, its therapeutic …
Cancer combination therapies with artemisinin-type drugs
T Efferth - Biochemical pharmacology, 2017 - Elsevier
Artemisia annua L. is a Chinese medicinal plant, which is used throughout Asia and Africa
as tea or press juice to treat malaria. The bioactivity of its chemical constituent, artemisinin is …
as tea or press juice to treat malaria. The bioactivity of its chemical constituent, artemisinin is …
Carrier-enhanced anticancer efficacy of sunitinib-loaded green tea-based micellar nanocomplex beyond tumor-targeted delivery
N Yongvongsoontorn, JE Chung, SJ Gao, KH Bae… - Acs Nano, 2019 - ACS Publications
Although a few nanomedicines have been approved for clinical use in cancer treatment, that
recognizes improved patient safety through targeted delivery, their improved efficacy over …
recognizes improved patient safety through targeted delivery, their improved efficacy over …
Melatonin targets MoIcl1 and works synergistically with fungicide isoprothiolane in rice blast control
Melatonina natural harmless molecule—displays versatile roles in human health and crop
disease control such as for rice blast. Rice blast, caused by the filamentous fungus …
disease control such as for rice blast. Rice blast, caused by the filamentous fungus …
Synergistic inhibition of isolated flavonoids from Moringa oleifera leaf on α-glucosidase activity
Flavonoids are phenolic substances naturally distributed in plants with potential antidiabetic
activity through the inhibition of α-glucosidase. Therefore, the present study investigated the …
activity through the inhibition of α-glucosidase. Therefore, the present study investigated the …
Glycyrrhizic acid enhances the anticancer activity of cisplatin in the human ovarian cancer cell line
F Omidi, S Shahbazi, S Reiisi, S Azhdari… - Toxicology in Vitro, 2023 - Elsevier
This study aimed to investigate the effects of glycyrrhizic acid (GL) on the anticancer activity
of cisplatin in A2780 ovarian cancer cells. Cultured A2780 cells were treated with different …
of cisplatin in A2780 ovarian cancer cells. Cultured A2780 cells were treated with different …
Cyclin-dependent kinases (CDKs) and the human cytomegalovirus-encoded CDK ortholog pUL97 represent highly attractive targets for synergistic drug combinations
M Wild, F Hahn, N Brückner, M Schütz… - International Journal of …, 2022 - mdpi.com
Human cytomegalovirus (HCMV) is a pathogenic human herpesvirus associated with
serious, potentially life-threatening symptoms in the immunocompromised or immunonaïve …
serious, potentially life-threatening symptoms in the immunocompromised or immunonaïve …