The reconstruction of large defects (> 10 mm) in humans usually relies on bone graft
transplantation. Limiting factors include availability of graft material, comorbidity, and …

Critical-size bone defects, which require large-volume tissue reconstruction, remain a
clinical challenge. Bone engineering has the potential to provide new treatment concepts …

Background We describe the first clinical series of a novel bone replacement technique
based on regenerative matching axial vascularisation (RMAV). This was used in four cases …

The development of bone substitute materials (BSMs) intended for load-bearing bone
defects is highly complicated, as biological and mechanical requirements are often …

Fracture-related infections (FRIs) are among the most common complications following
fracture fixation, and they have a huge economic and functional impact on patients. Because …

Triply Periodic Minimal Surfaces (TPMS) are promising structures for bone tissue
engineering scaffolds due to their relatively high mechanical energy absorption, smoothly …

Background In 1986, Marko Godina published his seminal work regarding the timing of free-
flap reconstruction for traumatic extremity defects. Early reconstruction, compared with …

Fracture related infection (FRI) remains one of the most challenging complications of
orthopaedic trauma surgery. Several factors contribute to FRI development but, among …

Objectives: To evaluate the incidence of nonunion and wound complications after open,
complete articular pilon fractures. Second, to study the effect that both timing of fixation and …

Results: Wound cover was achieved with 24 distant free muscle flaps, four local rotational
muscle flaps and five fasciocutaneous flaps. All fractures united with an average time to …