Microbes are unique creatures that adapt to varying lifestyles and environment resistance in
extreme or adverse conditions. The genetic architecture of microbe may bear a significant …

Hydroxylamines and their derivatives have found a wide range of applications in organic
synthesis. 1 In this review we hope to cover the synthetic applications of N …

Emerging influenza viruses are a serious threat to human health because of their pandemic
potential. A promising target for the development of novel anti-influenza therapeutics is the …

Metalloenzymes are central to the regulation of a wide range of essential viral and parasitic
functions, including protein degradation, nucleic acid modification, and many others. Given …

The dihydroxypyrimidine carboxamide 4a was discovered as a potent and selective HIV
integrase strand transfer inhibitor. The optimization of physicochemical properties …

More than 20 years after the identification of the hepatitis C virus (HCV) as a novel human
pathogen, the only approved treatment remains a combination of pegylated interferon-α and …

Synthesis and structural characterization of nano crystallites of bis-violurate-based
manganese (II) and copper (II) chelates is the subject of the present study. Analytical data …

Pyrimidinol carboxylic acids were designed as inhibitors of HIV-1 RNase H function. These
molecules can coordinate to two divalent metal ions in the RNase H active site. Inhibition of …

The global prevalence of hepatitis C virus (HCV) infection and the serious consequences
associated with the chronic state of the disease have become a worldwide health problem. A …

Human immunodeficiency virus type-1 (HIV-1) integrase, one of the three constitutive viral
enzymes required for replication, is a rational target for chemotherapeutic intervention in the …