Carbohydrate metabolism in trypanosomatids: New insights revealing novel complexity, diversity and species-unique features
PAM Michels, O Villafraz, E Pineda, MB Alencar… - Experimental …, 2021 - Elsevier
The human pathogenic trypanosomatid species collectively called the “TriTryp parasites”–
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …
Combining reverse genetics and nuclear magnetic resonance‐based metabolomics unravels trypanosome‐specific metabolic pathways
Numerous eukaryotes have developed specific metabolic traits that are not present in
extensively studied model organisms. For instance, the procyclic insect form of T …
extensively studied model organisms. For instance, the procyclic insect form of T …
Procyclic trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in the presence of physiological amounts of proline
O Villafraz, M Biran, E Pineda, N Plazolles… - PLoS …, 2021 - journals.plos.org
Trypanosoma brucei, a protist responsible for human African trypanosomiasis (slee**
sickness), is transmitted by the tsetse fly where the procyclic forms of the parasite develop in …
sickness), is transmitted by the tsetse fly where the procyclic forms of the parasite develop in …
Cytosolic NADPH homeostasis in glucose-starved procyclic Trypanosoma brucei relies on malic enzyme and the pentose phosphate pathway fed by gluconeogenic …
All living organisms depend on NADPH production to feed essential biosyntheses and for
oxidative stress defense. Protozoan parasites such as the slee** sickness pathogen …
oxidative stress defense. Protozoan parasites such as the slee** sickness pathogen …
Bioenergetic consequences of FoF1–ATP synthase/ATPase deficiency in two life cycle stages of Trypanosoma brucei
Mitochondrial ATP synthase is a reversible nanomotor synthesizing or hydrolyzing ATP
depending on the potential across the membrane in which it is embedded. In the unicellular …
depending on the potential across the membrane in which it is embedded. In the unicellular …
Contribution of pyruvate phosphate dikinase in the maintenance of the glycosomal ATP/ADP balance in the Trypanosoma brucei procyclic form
Trypanosoma brucei belongs to a group of protists that sequester the first six or seven
glycolytic steps inside specialized peroxisomes, named glycosomes. Because of the …
glycolytic steps inside specialized peroxisomes, named glycosomes. Because of the …
Dissecting Leishmania infantum Energy Metabolism - A Systems Perspective
Leishmania infantum, causative agent of visceral leishmaniasis in humans, illustrates a
complex lifecycle pertaining to two extreme environments, namely, the gut of the sandfly …
complex lifecycle pertaining to two extreme environments, namely, the gut of the sandfly …
Drug target identification through systems biology
To rationalise drug target selection, we should understand the role of putative targets in
biological pathways quantitatively. We review here how experimental and computational …
biological pathways quantitatively. We review here how experimental and computational …
Network Modeling and Control of Dynamic Disease Pathways, Review and Perspectives
Dynamic disease pathways are a combination of complex dynamical processes among bio-
molecules in a cell that leads to diseases. Network modeling of disease pathways considers …
molecules in a cell that leads to diseases. Network modeling of disease pathways considers …
Exploring metabolism flexibility in complex organisms through quantitative study of precursor sets for system outputs
O Abdou-Arbi, S Lemosquet, JV Milgen, A Siegel… - BMC systems …, 2014 - Springer
Background When studying metabolism at the organ level, a major challenge is to
understand the matter exchanges between the input and output components of the system …
understand the matter exchanges between the input and output components of the system …