2-Oxoglutarate-dependent dioxygenases in cancer
JA Losman, P Koivunen, WG Kaelin Jr - Nature Reviews Cancer, 2020 - nature.com
Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …
Current and future trends on diagnosis and prognosis of glioblastoma: from molecular biology to proteomics
Glioblastoma multiforme is the most aggressive malignant tumor of the central nervous
system. Due to the absence of effective pharmacological and surgical treatments, the …
system. Due to the absence of effective pharmacological and surgical treatments, the …
2-Hydroxyglutarate in cancer cells
P Ježek - Antioxidants & redox signaling, 2020 - liebertpub.com
Significance: Cancer cells are stabilized in an undifferentiated state similar to stem cells.
This leads to profound modifications of their metabolism, which further modifies their …
This leads to profound modifications of their metabolism, which further modifies their …
Non-IDH1-R132H IDH1/2 mutations are associated with increased DNA methylation and improved survival in astrocytomas, compared to IDH1-R132H mutations
CMS Tesileanu, WR Vallentgoed, M Sanson… - Acta …, 2021 - Springer
Somatic mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 occur at high
frequency in several tumour types. Even though these mutations are confined to distinct …
frequency in several tumour types. Even though these mutations are confined to distinct …
Handheld mass spectrometer with intelligent adaptability for on-site and point-of-care analysis
The development of miniature mass spectrometry (MS) systems with simple analysis
procedures is important for the transition of applying MS analysis outside traditional …
procedures is important for the transition of applying MS analysis outside traditional …
[HTML][HTML] Epilepsy and brain tumors: Two sides of the same coin
E Aronica, E Ciusani, A Coppola, C Costa… - Journal of the …, 2023 - Elsevier
Epilepsy is the most common symptom in patients with brain tumors. The shared genetic,
molecular, and cellular mechanisms between tumorigenesis and epileptogenesis represent …
molecular, and cellular mechanisms between tumorigenesis and epileptogenesis represent …
The clinical use of IDH1 and IDH2 mutations in gliomas
Introduction: Mutations in the genes isocitrate dehydrogenase (IDH) 1 and 2 have been
reported in a limited number of tumors. In gliomas, IDH mutations are primarily detected in …
reported in a limited number of tumors. In gliomas, IDH mutations are primarily detected in …
Metabolic reprogramming in the pathogenesis of glioma: Update
Cancer is a genetic disease that is currently classified not only by its tissue and cell type of
origin but increasingly by its molecular composition. Increasingly, tumor classification and …
origin but increasingly by its molecular composition. Increasingly, tumor classification and …
Mass spectrometry advances in analysis of glioblastoma
Some cancers such as glioblastoma (GBM), show minimal response to medical
interventions, often only capable of mitigating tumor growth or alleviating symptoms. High …
interventions, often only capable of mitigating tumor growth or alleviating symptoms. High …
Complementarity of matrix-and nanostructure-assisted laser desorption/ionization approaches
In recent years, matrix-assisted laser desorption/ionization (MALDI) has become the main
tool for the study of biological macromolecules, such as protein nano-machines, especially …
tool for the study of biological macromolecules, such as protein nano-machines, especially …