Dual inhibitors of human DNA topoisomerase II and other cancer-related targets
Human DNA topoisomerase II is an important target in anticancer therapy. Despite the
clinical success of drugs that target topoisomerase II, the development of resistant cancer …
clinical success of drugs that target topoisomerase II, the development of resistant cancer …
A comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade
X Liang, Q Wu, S Luan, Z Yin, C He, L Yin, Y Zou… - European journal of …, 2019 - Elsevier
The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …
Advances in synthetic strategies and medicinal importance of benzofurans: A review
D Dwarakanath, SL Gaonkar - Asian Journal of Organic …, 2022 - Wiley Online Library
Out of the many heterocycles that exhibit pharmaceutical and therapeutic properties,
benzofurans remain the most eye‐catching to scientists ever since their discovery. From …
benzofurans remain the most eye‐catching to scientists ever since their discovery. From …
DNA binding and Topoisomerase inhibition: How can these mechanisms be explored to design more specific anticancer agents?
SMV de Almeida, AG Ribeiro, GC de Lima Silva… - Biomedicine & …, 2017 - Elsevier
DNA is considered one of the most promising targets of molecules with anticancer activity
potential. Its key role in various cell division mechanisms, which commands the intense …
potential. Its key role in various cell division mechanisms, which commands the intense …
Aurones: synthesis and properties
AV Popova, SP Bondarenko, MS Frasinyuk - Chemistry of Heterocyclic …, 2019 - Springer
This article provides generalized and systematic overview of data on the synthesis,
stereoisomerism, and reactivity of aurones (2-benzylidenebenzofuran-3 (2 Н)-ones) …
stereoisomerism, and reactivity of aurones (2-benzylidenebenzofuran-3 (2 Н)-ones) …