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Insights into protein–ligand interactions: mechanisms, models, and methods
X Du, Y Li, YL ** of mutations at single-nucleotide resolution for protein, metabolic and genome engineering
Improvements in DNA synthesis and sequencing have underpinned comprehensive
assessment of gene function in bacteria and eukaryotes. Genome-wide analyses require …
assessment of gene function in bacteria and eukaryotes. Genome-wide analyses require …
Structure determination of high-energy states in a dynamic protein ensemble
JB Stiller, R Otten, D Häussinger, PS Rieder… - Nature, 2022 - nature.com
Macromolecular function frequently requires that proteins change conformation into high-
energy states,,–. However, methods for solving the structures of these functionally essential …
energy states,,–. However, methods for solving the structures of these functionally essential …
Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch
A Bah, RM Vernon, Z Siddiqui, M Krzeminski… - Nature, 2015 - nature.com
Intrinsically disordered proteins play important roles in cell signalling, transcription,
translation and cell cycle regulation,. Although they lack stable tertiary structure, many …
translation and cell cycle regulation,. Although they lack stable tertiary structure, many …
Ratcheting synthesis
Synthetic chemistry has traditionally relied on reactions between reactants of high chemical
potential and transformations that proceed energetically downhill to either a global or local …
potential and transformations that proceed energetically downhill to either a global or local …
Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism
Enzymes catalyze biochemical reactions through precise positioning of substrates,
cofactors, and amino acids to modulate the transition-state free energy. However, the role of …
cofactors, and amino acids to modulate the transition-state free energy. However, the role of …
The role of dynamic conformational ensembles in biomolecular recognition
Molecular recognition is central to all biological processes. For the past 50 years,
Koshland's' induced fit'hypothesis has been the textbook explanation for molecular …
Koshland's' induced fit'hypothesis has been the textbook explanation for molecular …
An introduction to NMR-based approaches for measuring protein dynamics
Proteins are inherently flexible at ambient temperature. At equilibrium, they are
characterized by a set of conformations that undergo continuous exchange within a …
characterized by a set of conformations that undergo continuous exchange within a …
Parallel molecular mechanisms for enzyme temperature adaptation
INTRODUCTION Over billions of years, organisms and their enzymes have been evolving
and adapting in response to selection pressures from their environments. In particular …
and adapting in response to selection pressures from their environments. In particular …