Mechanism and role of PDZ domains in signaling complex assembly
BZ Harris, WA Lim - Journal of cell science, 2001 - journals.biologists.com
PDZ domains are protein-protein recognition modules that play a central role in organizing
diverse cell signaling assemblies. These domains specifically recognize short C-terminal …
diverse cell signaling assemblies. These domains specifically recognize short C-terminal …
Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions
L Funke, S Dakoji, DS Bredt - Annu. Rev. Biochem., 2005 - annualreviews.org
▪ Abstract Tissue development, differentiation, and physiology require specialized cellular
adhesion and signal transduction at sites of cell-cell contact. Scaffolding proteins that tether …
adhesion and signal transduction at sites of cell-cell contact. Scaffolding proteins that tether …
Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins
Membrane-associated guanylate kinases (MAGUKs), such as PSD-95, are modular
scaffolds that organize signaling complexes at synapses and other cell junctions. MAGUKs …
scaffolds that organize signaling complexes at synapses and other cell junctions. MAGUKs …
PTEN controls tumor-induced angiogenesis
S Wen, J Stolarov, MP Myers, JD Su… - Proceedings of the …, 2001 - National Acad Sciences
Mutations of the tumor suppressor PTEN, a phosphatase with specificity for 3-
phosphorylated inositol phospholipids, accompany progression of brain tumors from benign …
phosphorylated inositol phospholipids, accompany progression of brain tumors from benign …
[HTML][HTML] Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions
Single-particle electron microscopy (EM) combined with biochemical measurements
revealed the molecular shape of SAP97 and a monomer-dimer transition that depended on …
revealed the molecular shape of SAP97 and a monomer-dimer transition that depended on …
Interaction of SAP97 with minus-end-directed actin motor myosin VI: implications for AMPA receptor trafficking
SAP97 is a modular protein composed of three PDZ domains, an SH3 domain, and a
guanylate kinase-like domain. It has been implicated functionally in the assembly and …
guanylate kinase-like domain. It has been implicated functionally in the assembly and …
A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral surface of epithelia
S Lee, S Fan, O Makarova, S Straight… - Molecular and cellular …, 2002 - Taylor & Francis
Mammalian Lin-2 (mLin-2)/CASK is a membrane-associated guanylate kinase (MAGUK)
and contains multidomain modules that mediate protein-protein interactions important for the …
and contains multidomain modules that mediate protein-protein interactions important for the …
Self-association of PAR-3-mediated by the conserved N-terminal domain contributes to the development of epithelial tight junctions
PAR-3 is a scaffold-like PDZ-containing protein that forms a complex with PAR-6 and
atypical protein kinase C (PAR-3-atypical protein kinase C-PAR-6 complex) and contributes …
atypical protein kinase C (PAR-3-atypical protein kinase C-PAR-6 complex) and contributes …
Somatic Mutations and Altered Expression of the Candidate Tumor Suppressors CSNK1ε, DLG1, and EDD/hHYD in Mammary Ductal Carcinoma
TJ Fuja, F Lin, KE Osann, PJ Bryant - Cancer research, 2004 - AACR
We report somatic mutations in three genes (CSNK1 ε, encoding the Ser/Thr kinase casein
kinase I ε; DLG1, encoding a membrane-associated putative scaffolding protein; and …
kinase I ε; DLG1, encoding a membrane-associated putative scaffolding protein; and …
GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes
T Hanada, L Lin, EV Tibaldi, EL Reinherz… - Journal of Biological …, 2000 - ASBMB
Reorganization of the cortical cytoskeleton is a hallmark of T lymphocyte activation. Upon
binding to antigen presenting cells, the T cells rapidly undergo cytoskeletal re-organization …
binding to antigen presenting cells, the T cells rapidly undergo cytoskeletal re-organization …