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The biology and pathobiology of glutamatergic, cholinergic, and dopaminergic signaling in the aging brain
A Gasiorowska, M Wydrych, P Drapich… - Frontiers in aging …, 2021 - frontiersin.org
The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …
implications. Clinical and experimental studies on aging have uncovered numerous …
A Guide to the Metabolic Pathways and Function of Metabolites Observed in Human Brain 1H Magnetic Resonance Spectra
The current knowledge of the normal biochemistry of compounds that give rise to
resonances in human brain proton magnetic resonance spectra measureable at readily …
resonances in human brain proton magnetic resonance spectra measureable at readily …
Glutamate: a truly functional amino acid
JT Brosnan, ME Brosnan - Amino acids, 2013 - Springer
Glutamate is one of the most abundant of the amino acids. In addition to its role in protein
structure, it plays critical roles in nutrition, metabolism and signaling. Post-translational …
structure, it plays critical roles in nutrition, metabolism and signaling. Post-translational …
Glutamate and glutamine: a review of in vivo MRS in the human brain
Our understanding of the roles that the amino acids glutamate (Glu) and glutamine (Gln)
play in the mammalian central nervous system has increased rapidly in recent times. Many …
play in the mammalian central nervous system has increased rapidly in recent times. Many …
[HTML][HTML] Alcoholism: a systems approach from molecular physiology to addictive behavior
Alcohol consumption is an integral part of daily life in many societies. The benefits
associated with the production, sale, and use of alcoholic beverages come at an enormous …
associated with the production, sale, and use of alcoholic beverages come at an enormous …
[HTML][HTML] Brain GABA and glutamate levels across pain conditions: A systematic literature review and meta-analysis of 1H-MRS studies using the MRS-Q quality …
Background A proposed mechanism of chronic pain is dysregulation between the main
inhibitory (GABA) and excitatory (glutamate) neurometabolites of the central nervous system …
inhibitory (GABA) and excitatory (glutamate) neurometabolites of the central nervous system …
The regulation of astrocytic glutamate transporters in health and neurodegenerative diseases
The astrocytic glutamate transporters excitatory amino acid transporters 1 and 2 (EAAT1 and
EAAT2) play a key role in nervous system function to maintain extracellular glutamate levels …
EAAT2) play a key role in nervous system function to maintain extracellular glutamate levels …
Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T
Histopathological reports of multiple sclerosis and its animal models have shown evidence
of a link between axonal injury in active lesions and impaired glutamate metabolism. Mature …
of a link between axonal injury in active lesions and impaired glutamate metabolism. Mature …
Edited 1H magnetic resonance spectroscopy in vivo: Methods and metabolites
The Proton magnetic resonance (1H‐MRS) spectrum contains information about the
concentration of tissue metabolites within a predefined region of interest (a voxel). The …
concentration of tissue metabolites within a predefined region of interest (a voxel). The …
Elevated insular glutamate in fibromyalgia is associated with experimental pain
Objective Central pain augmentation resulting from enhanced excitatory and/or decreased
inhibitory neurotransmission is a proposed mechanism underlying the pathophysiology of …
inhibitory neurotransmission is a proposed mechanism underlying the pathophysiology of …