Uveal melanoma (UM), a rare cancer of the eye, is distinct from cutaneous melanoma by its
etiology, the mutation frequency and profile, and its clinical behavior including resistance to …

The variation in mouse coat color provides the most effective example of the mechanisms
involved in gene expression. Studies suggested that mutations during gene expression and …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

Although metastasis is the leading cause of cancer-related death, it is not clear why some
patients with localized cancer develop metastatic disease after complete resection of their …

Extant evidence implicates growth factor signaling in the pathogenesis of many tumor types,
including cutaneous melanoma. Recently, reciprocal activating mutations of NRAS and …

Multiple endocrine neoplasia type 2B (MEN 2B) is a human cancer syndrome characterized
by medullary thyroid carcinoma (MTC), pheochromocytomas, mucosal neuromas …

The familial melanoma gene (INK4a/MTS1/CDKN2) encodes potent tumor suppressor
activity. Although mice null for the ink4a homolog develop a cancer-prone condition, a …

We report here on a novel metallothionein-I (MT)/ret transgenic mouse line in which skin
melanosis, benign melanocytic tumor and malignant melanoma metastasizing to distant …

Cutaneous melanoma is a complex disorder characterized by an elevated degree of
heterogeneity, features that place it among the most aggressive types of cancer. Although …

In vitro, normal human melanocytes require synergistic mitogens, in addition to the common
growth factors present in serum, in order to proliferate. The peptide growth factors that confer …