Signal pathways of melanoma and targeted therapy

W Guo, H Wang, C Li - Signal transduction and targeted therapy, 2021‏ - nature.com
Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

The potential of plant phenolics in prevention and therapy of skin disorders

M Działo, J Mierziak, U Korzun, M Preisner… - International journal of …, 2016‏ - mdpi.com
Phenolic compounds constitute a group of secondary metabolites which have important
functions in plants. Besides the beneficial effects on the plant host, phenolic metabolites …

The melanoma revolution: from UV carcinogenesis to a new era in therapeutics

JA Lo, DE Fisher - Science, 2014‏ - science.org
Melanoma, the deadliest form of skin cancer, is an aggressive disease that is rising in
incidence. Although melanoma is a historically treatment-resistant malignancy, in recent …

The Protective Role of Melanin Against UV Damage in Human Skin

M Brenner, VJ Hearing - Photochemistry and photobiology, 2008‏ - Wiley Online Library
Human skin is repeatedly exposed to UVR that influences the function and survival of many
cell types and is regarded as the main causative factor in the induction of skin cancer. It has …

[HTML][HTML] The HIrisPlex system for simultaneous prediction of hair and eye colour from DNA

S Walsh, F Liu, A Wollstein, L Kovatsi, A Ralf… - Forensic Science …, 2013‏ - Elsevier
Recently, the field of predicting phenotypes of externally visible characteristics (EVCs) from
DNA genotypes with the final aim of concentrating police investigations to find persons …

Melanocyte biology and skin pigmentation

JY Lin, DE Fisher - Nature, 2007‏ - nature.com
Melanocytes are phenotypically prominent but histologically inconspicuous skin cells. They
are responsible for the pigmentation of skin and hair, and thereby contribute to the …

G-protein-coupled receptors and cancer

RT Dorsam, JS Gutkind - Nature reviews cancer, 2007‏ - nature.com
G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved
in signal transmission, have recently emerged as crucial players in tumour growth and …

[ספר][B] Handbook of cosmetic science and technology

AO Barel, M Paye, HI Maibach - 2014‏ - books.google.com
Written by experienced and internationally renowned contributors, this is the fourth edition of
what has become the standard reference for cosmetic scientists and dermatologists seeking …

[HTML][HTML] Melanoma epidemiology, biology and prognosis

Z Ali, N Yousaf, J Larkin - European Journal of Cancer Supplements, 2013‏ - Elsevier
Melanoma is a cancer arising from the malignant transformation of melanocytes. These
pigment-producing cells derive embryologically from pluripotent neural crest stem cells …

Structure of human tyrosinase related protein 1 reveals a binuclear zinc active site important for melanogenesis

X Lai, HJ Wichers, M Soler‐Lopez… - Angewandte Chemie …, 2017‏ - Wiley Online Library
Abstract Tyrosinase‐related protein 1 (TYRP1) is one of three tyrosinase‐like glycoenzymes
in human melanocytes that are key to the production of melanin, the compound responsible …