Signal pathways of melanoma and targeted therapy

W Guo, H Wang, C Li - Signal transduction and targeted therapy, 2021 - nature.com
Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

The potential of plant phenolics in prevention and therapy of skin disorders

M Działo, J Mierziak, U Korzun, M Preisner… - International journal of …, 2016 - mdpi.com
Phenolic compounds constitute a group of secondary metabolites which have important
functions in plants. Besides the beneficial effects on the plant host, phenolic metabolites …

The melanoma revolution: from UV carcinogenesis to a new era in therapeutics

JA Lo, DE Fisher - Science, 2014 - science.org
Melanoma, the deadliest form of skin cancer, is an aggressive disease that is rising in
incidence. Although melanoma is a historically treatment-resistant malignancy, in recent …

[HTML][HTML] Pode a genética definir quem deve se beneficiar das cotas universitárias e demais ações afirmativas?

SDJ Pena, MC Bortolini - Estudos avançados, 2004 - SciELO Brasil
NESTE TRABALHO nós usamos o instrumental da genética molecular e da genética de
populações para estimar quantitativamente a contribuição africana para a formação do …

The Protective Role of Melanin Against UV Damage in Human Skin

M Brenner, VJ Hearing - Photochemistry and photobiology, 2008 - Wiley Online Library
Human skin is repeatedly exposed to UVR that influences the function and survival of many
cell types and is regarded as the main causative factor in the induction of skin cancer. It has …

[HTML][HTML] The HIrisPlex system for simultaneous prediction of hair and eye colour from DNA

S Walsh, F Liu, A Wollstein, L Kovatsi, A Ralf… - Forensic Science …, 2013 - Elsevier
Recently, the field of predicting phenotypes of externally visible characteristics (EVCs) from
DNA genotypes with the final aim of concentrating police investigations to find persons …

Melanocyte biology and skin pigmentation

JY Lin, DE Fisher - Nature, 2007 - nature.com
Melanocytes are phenotypically prominent but histologically inconspicuous skin cells. They
are responsible for the pigmentation of skin and hair, and thereby contribute to the …

G-protein-coupled receptors and cancer

RT Dorsam, JS Gutkind - Nature reviews cancer, 2007 - nature.com
G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved
in signal transmission, have recently emerged as crucial players in tumour growth and …

Fisiopatologia do melasma

LDB Miot, HA Miot, MG Silva… - Anais brasileiros de …, 2009 - SciELO Brasil
Melasma é uma dermatose comum que cursa com alteração da cor da pele normal,
resultante da hiperatividade melanocítica focal epidérmica de clones de melanócitos …

Razões para banir o conceito de raça da medicina brasileira

SDJ Pena - História, Ciências, Saúde-Manguinhos, 2005 - SciELO Brasil
O conceito de'raça'faz parte do arcabouço canônico da medicina, associado à idéia de que
cor e/ou ancestralidade biológica são relevantes como indicadores de predisposição a …