The barrier between the blood and the ventricular cerebrospinal fluid (CSF) is located at the
choroid plexuses. At the interface between two circulating fluids, these richly vascularized …

The central nervous system (CNS) comprises the brain, spinal cord, optic nerves and retina,
and contains post-mitotic, delicate cells. As the rigid coverings of the CNS render swelling …

The central nervous system (CNS) is an immunologically privileged site to which access of
circulating immune cells is tightly controlled by the endothelial blood–brain barrier (BBB; see …

The mechanisms of communication between the brain and the immune cells are still largely
unclear. Here, we characterize the populations of resident natural killer (NK) cells and innate …

Complex barriers separate immune-privileged tissues from the circulation. Here, we propose
that cell entry to immune-privileged sites through barriers composed of tight junction …

Inflammation is an integral part of the body's physiological repair mechanism, unless it
remains unresolved and becomes pathological, as evident in the progressive nature of …

The CNS is an immune-privileged environment, yet the local control of multiple pathogens is
dependent on the ability of immune cells to access and operate within this site. However …

This review addresses current knowledge of the molecular trafficking signals involved in the
migration of circulating leukocytes across the highly specialized blood–central nervous …

The choroid plexus is composed of epithelial cells resting on a basal lamina. These cells
produce the cerebrospinal fluid (CSF), which has many functions including rendering …

The choroid plexus is a multifunctional organ that sits at the interface between the blood and
cerebrospinal fluid (CSF). It serves as a gateway for immune cell trafficking into the CSF and …