Parkinson's disease is a common progressive neurodegenerative disease, and presently
has no curative agent. Curcumin, as one of the natural polyphenols, has great potential in …

Breast cancer stands as the most prevalent cancer in women globally, and contributes to the
highest percentage of mortality due to cancer-related deaths in women. Paclitaxel (PTX) is …

(3-Substitutedphenyl-5-polymethoxyphenyl-4, 5-dihydro-1H-pyrazol-1-yl)
benzenesulfonamides (9–16) were synthesized and their chemical structures were …

The isoenzyme of human glutathione transferase P1-1 (hGSTP1-1) is involved in multi-drug
resistance (MDR) mechanisms in numerous cancer cell lines. In the present study, the …

Introduction: Chalcones are attractive to synthetic chemists because they are easy to
prepare, have a large number of replaceable hydrogens, thereby having significant …

This report summarizes the latest published data on the antiproliferative action and cytotoxic
activity of Mannich bases, a structurally heterogeneous category of chemical entities that …

Background: Phenolic Mannich bases have been reported as acetylcholinesterase (AChE)
inhibitors for the medication of Alzheimer's disease. Carbonic Anhydrases (CAs) are …

Breast cancer (BC), the most common malignancy in women, results from significant
alterations in genetic and epigenetic mechanisms that alter multiple signaling pathways in …

Ischemia-reperfusion injury (IRI) is an inevitable pathological process after organic
transplantations. Although traditional treatments restore the blood supply of ischemic …

Breast cancer is one of the most common causes of mortality in women. Lupiwighteone has
anticancer effects in prostate cancer cells and neuroblastoma cells. However, the molecular …