Fluid–structure interaction analyses of biological systems using smoothed-particle hydrodynamics

M Toma, R Chan-Akeley, J Arias, GD Kurgansky… - Biology, 2021‏ - mdpi.com
Simple Summary Computational simulations of biological systems are an intrinsic element of
engineering in medicine, allowing physicians the ability to visualize the pathophysiology …

The influence of respiration on blood flow in the Fontan circulation: insights for imaging-based clinical evaluation of the total cavopulmonary connection

SLFS Van der Woude, FM Rijnberg… - Frontiers in …, 2021‏ - frontiersin.org
Congenital heart disease is the most common birth defect and functionally univentricular
heart defects represent the most severe end of this spectrum. The Fontan circulation …

Fluid-structure interaction simulation of an intra-atrial fontan connection

E Tang, Z Wei, MA Fogel, A Veneziani, AP Yoganathan - Biology, 2020‏ - mdpi.com
Simple Summary A fluid-structure interaction (FSI) simulation of an intra-atrial Fontan
connection was performed. Power loss and pressure drop results fluctuated less during the …

Computational fluid dynamics support for fontan planning in minutes, not hours: the next step in clinical pre-interventional simulations

P Frieberg, N Aristokleous, P Sjöberg, J Töger… - Journal of …, 2022‏ - Springer
Computational fluid dynamics (CFD) modeling may aid in planning of invasive interventions
in Fontan patients. Clinical application of current CFD techniques is however limited by …

Effects of cardiac growth on electrical dyssynchrony in the single ventricle patient

OZ Tikenoğulları, M Peirlinck, H Chubb… - Computer methods in …, 2024‏ - Taylor & Francis
Single ventricle patients, including those with hypoplastic left heart syndrome (HLHS),
typically undergo three palliative heart surgeries culminating in the Fontan procedure. HLHS …

[HTML][HTML] The first cohort of prospective Fontan surgical planning patients with follow-up data: How accurate is surgical planning?

PM Trusty, ZA Wei, TC Slesnick, KR Kanter… - The Journal of thoracic …, 2019‏ - Elsevier
Objective Fontan surgical planning is an image-based, collaborative effort, which is
hypothesized to result in improved patient outcomes. A common motivation for Fontan …

Fontan circulation of the next generation: why it's necessary, what it might look like

S Kutty, ML Jacobs, WR Thompson… - Journal of the American …, 2020‏ - ahajournals.org
Not many decades ago, it was the rare patient with a functionally univentricular heart who
survived to adulthood. 1 While this grim prognosis has gradually improved over the years …

Mending a broken heart: In vitro, in vivo and in silico models of congenital heart disease

AJ Rufaihah, CK Chen, CH Yap… - Disease Models & …, 2021‏ - journals.biologists.com
Birth defects contribute to∼ 0.3% of global infant mortality in the first month of life, and
congenital heart disease (CHD) is the most common birth defect among newborns …

In vivo hepatic flow distribution by computational fluid dynamics can predict pulmonary flow distribution in patients with Fontan circulation

P Frieberg, P Sjöberg, E Hedström, M Carlsson… - Scientific Reports, 2023‏ - nature.com
In Fontan patients, a lung deprived of hepatic blood may develop pulmonary arterio-venous
malformations (PAVMs) resulting in shunting, reduced pulmonary vascular resistance (PVR) …

Non-Newtonian effects on patient-specific modeling of Fontan hemodynamics

Z Wei, S Singh-Gryzbon, PM Trusty… - Annals of biomedical …, 2020‏ - Springer
The Fontan procedure is a common palliative surgery for congenital single ventricle patients.
In silico and in vitro patient-specific modeling approaches are widely utilized to investigate …