Randomized experiments have enormous potential to improve human welfare in many
domains, including healthcare, education, finance, and public policy. However, such “A/B …

Different models of learning health systems are emerging. At Vanderbilt University Medical
Center, the Learning Health Care System (LHS) Platform was established with the goal of …

Importance COVID-19 vaccine uptake among urban populations remains low. Objective To
evaluate whether text messaging with outbound or inbound scheduling and behaviorally …

OBJECTIVES: Colorectal cancer (CRC) screening uptake is suboptimal, despite national
efforts to increase screening rates. Behavioral economic approaches such as changing …

Importance Despite public health efforts, breast cancer screening rates remain below
national goals. Objective To evaluate whether bulk ordering, text messaging, and clinician …

Background: Surveillance rates for HCC remain limited in patients with cirrhosis. We
evaluated whether opt-out mailed outreach increased uptake with or without a $20 …

Importance Mailing fecal immunochemical test (FIT) kits to patients' homes has been shown
to boost colorectal cancer screening rates, but response rates remain limited, and organized …

Background Routine screening reduces colorectal cancer mortality, but screening rates fall
below national targets and are particularly low in underserved populations. Objective To …

Importance Hepatitis C virus (HCV) screening has been recommended for patients born
between 1945 and 1965, but rates remain low. Objective To evaluate whether a default …

There is intense debate around the use of altered and waived consent for pragmatic trials.
Those in favor argue that traditional consent compromises the internal and external validity …