Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic as well as
reproductive disorder conferring substantially increased risk for type 2 diabetes. Affected …

Background Haemoglobinopathies constitute the commonest recessive monogenic
disorders worldwide, and the treatment of affected individuals presents a substantial global …

INTRODUCTION The consensus view on the peopling of the Americas is that ancestors of
modern Native Americans entered the Americas from Siberia via the Bering Land Bridge …

The gut microbiome modulates immune and metabolic health. Human microbiome data are
biased toward industrialized populations, limiting our understanding of non-industrialized …

We present an Aboriginal Australian genomic sequence obtained from a 100-year-old lock
of hair donated by an Aboriginal man from southern Western Australia in the early 20th …

Whole-genome sequences provide a rich source of information about human evolution.
Here we describe an effort to estimate key evolutionary parameters based on the whole …

Intergenerational effects on linear growth are well documented. Several generations are
necessary in animal models to 'wash out'effects of undernutrition, consistent with the …

Although range expansions have occurred recurrently in the history of most species, their
genetic consequences have been little investigated. Theoretical studies show that range …

There is little information on inbreeding during the critical early years of human existence.
However, given the small founding group sizes and restricted mate choices it seems …

Comparative studies of ethnically diverse human populations, particularly in Africa, are
important for reconstructing human evolutionary history and for understanding the genetic …