Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses among all
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …

Simple Summary PI3K signaling pathway plays an essential role in many cellular processes
and is frequently altered in breast cancer, leading to increased tumor growth and reduced …

Urological cancers have obtained much attention in recent years due to their mortality and
morbidity. The most common and malignant tumor of urological cancers is prostate cancer …

Selenium (Se) is indispensable in alleviating various types of intestinal injuries. Here, we
thoroughly investigated the protective effect of Se on the regulation of the epithelial cell–M2 …

Melanoma frequently harbors genetic alterations in key molecules leading to the aberrant
activation of PI3K and its downstream pathways. Although the role of PI3K/AKT/mTOR in …

Phosphoinositides, which are membrane-bound phospholipids, are critical signaling
molecules located at the interface between the extracellular matrix, cell membrane, and …

The Hippo pathway blocks epithelial-mesenchymal transition and metastasis in cancer
mediated by the transcriptional coactivator YAP. In this issue of Science Signaling, Palamiuc …

The biological processes of Chlamys farreri (C. farreri), an economically important shellfish,
are affected when exposed to Cd 2+. In this study, changes to biological processes and …

Alcohol-related liver fibrosis (ALF) is a form of alcohol-related liver disease (ALD) that
generally occurs in response to heavy long-term drinking. Ecto-5′-nucleotidase (NT5E) …

Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy, characterized by
a heterogeneous genetic landscape and complex clonal evolution, with poor outcomes …