Protocadherins at the crossroad of signaling pathways

A Pancho, T Aerts, MD Mitsogiannis… - Frontiers in Molecular …, 2020 - frontiersin.org
Protocadherins (Pcdhs) are cell adhesion molecules that belong to the cadherin
superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) …

Neurodevelopmental pathways in bipolar disorder

S Kloiber, JD Rosenblat, MI Husain, A Ortiz… - Neuroscience & …, 2020 - Elsevier
Aberrations in neurodevelopmental trajectories have been implicated in the neurobiology of
several mental disorders and evidence indicates a pathophysiological and genetic overlap …

Multi-ancestry genome-wide association study of major depression aids locus discovery, fine map**, gene prioritization and causal inference

X Meng, G Navoly, O Giannakopoulou, DF Levey… - Nature …, 2024 - nature.com
Most genome-wide association studies (GWAS) of major depression (MD) have been
conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD …

Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism

M Luciano, SP Hagenaars, G Davies, WD Hill… - Nature …, 2018 - nature.com
Neuroticism is a relatively stable personality trait characterized by negative emotionality (for
example, worry and guilt); heritability estimated from twin studies ranges from 30 to 50 …

A new agenda for personality psychology in the digital age?

C Montag, JD Elhai - Personality and Individual Differences, 2019 - Elsevier
The present paper hypothesizes how research in personality psychology will change with
the recent emergence of the Internet of Things (IoT). In a society, where humankind is …

Regulation of neural circuit formation by protocadherins

SL Peek, KM Mah, JA Weiner - Cellular and molecular life sciences, 2017 - Springer
The protocadherins (Pcdhs), which make up the most diverse group within the cadherin
superfamily, were first discovered in the early 1990s. Data implicating the Pcdhs, including …

Phenotypes, mechanisms and therapeutics: insights from bipolar disorder GWAS findings

M Li, T Li, X **ao, J Chen, Z Hu, Y Fang - Molecular Psychiatry, 2022 - nature.com
Genome-wide association studies (GWAS) have reported substantial genomic loci
significantly associated with clinical risk of bipolar disorder (BD), and studies combining …

The genome-wide risk alleles for psychiatric disorders at 3p21. 1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine

Z Yang, D Zhou, H Li, X Cai, W Liu, L Wang… - Molecular …, 2020 - nature.com
Schizophrenia and bipolar disorder (BPD) are believed to share clinical features, etiological
factors, and disease pathologies (such as impaired cognitive functions and dendritic spine …

Novel perspectives on the development of the amygdala in rodents

T Aerts, E Seuntjens - Frontiers in Neuroanatomy, 2021 - frontiersin.org
The amygdala is a hyperspecialized brain region composed of strongly inter-and
intraconnected nuclei involved in emotional learning and behavior. The cellular …

Prenatal androgen exposure causes a sexually dimorphic transgenerational increase in offspring susceptibility to anxiety disorders

S Risal, M Manti, H Lu, R Fornes, H Larsson… - Translational …, 2021 - nature.com
If and how obesity and elevated androgens in women with polycystic ovary syndrome
(PCOS) affect their offspring's psychiatric health is unclear. Using data from Swedish …