Subdivisions of the prefrontal cortex (PFC) evolved at different times. Agranular parts of the
PFC emerged in early mammals, and rodents, primates, and other modern mammals share …

The nervous system—in particular, the brain and its cognitive abilities—is among humans'
most distinctive and impressive attributes. How the nervous system has changed in the …

Adult cortical areas consist of specialized cell types and circuits that support unique higher-
order cognitive functions. How this regional diversity develops from an initially uniform …

Enhanced cognitive function in humans is hypothesized to result from cortical expansion
and increased cellular diversity. However, the mechanisms that drive these phenotypic …

In many applications, one is interested in determining which of the properties of a network
module change across conditions. For example, to validate the existence of a module, it is …

Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …

The Shape of Thought: How Mental Adaptations Evolve presents a road map for an
evolutionary psychology of the twenty-first century. It brings together theory from biology and …

A fundamental challenge in the post-genome era is to understand and annotate the
consequences of genetic variation, particularly within the context of human tissues. We …

For decades, evolutionary biologists have argued that changes in cis-regulatory sequences
constitute an important part of the genetic basis for adaptation. Although originally based on …

Background There is evidence that genes and their protein products are organized into
functional modules according to cellular processes and pathways. Gene co-expression …