Targeted drug delivery—from magic bullet to nanomedicine: principles, challenges, and future perspectives

A Tewabe, A Abate, M Tamrie, A Seyfu… - Journal of …, 2021 - Taylor & Francis
Nanomedicine is an advanced version of Paul Ehrlich's “magic bullet” concept. Targeted
drug delivery is a system of specifying the drug moiety directly into its targeted body area …

Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers

J Fang, W Islam, H Maeda - Advanced drug delivery reviews, 2020 - Elsevier
The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid
tumors that is related to their particular anatomical and pathophysiological characteristics …

Molecularly imprinted polymers: antibody mimics for bioimaging and therapy

K Haupt, PX Medina Rangel, BTS Bui - Chemical reviews, 2020 - ACS Publications
Molecularly imprinted polymers (MIPs) are tailor-made chemical receptors that recognize
and bind target molecules with a high affinity and selectivity. MIPs came into the spotlight in …

[HTML][HTML] The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy

Q Yang, N Guo, Y Zhou, J Chen, Q Wei… - Acta Pharmaceutica Sinica …, 2020 - Elsevier
Macrophages have a leading position in the tumor microenvironment (TME) which paves the
way to carcinogenesis. Initially, monocytes and macrophages are recruited to the sites …

Integrating bacteria with a ternary combination of photosensitizers for monochromatic irradiation-mediated photoacoustic imaging-guided synergistic photothermal …

H Guo, Z Cao, J Li, Z Fu, S Lin, L Wang, J Liu - ACS nano, 2023 - ACS Publications
Photosensitizer-based therapy often suffers from unitary and easily attenuated
photosensitive effects, limited tumor penetration and retention, and requirement of multiple …

Recent applications of PLGA based nanostructures in drug delivery

M Mir, N Ahmed, A ur Rehman - Colloids and Surfaces B: Biointerfaces, 2017 - Elsevier
Over the years, issues associated with non-biodegradable polymers have paved the way for
biodegradable polymers in the domain of pharmaceutical and biomedical sciences. Poly …

Rethinking CRITID procedure of brain targeting drug delivery: circulation, blood brain barrier recognition, intracellular transport, diseased cell targeting, internalization …

S Ruan, Y Zhou, X Jiang, H Gao - Advanced science, 2021 - Wiley Online Library
The past decades have witnessed great progress in nanoparticle (NP)‐based brain‐
targeting drug delivery systems, while their therapeutic potentials are yet to be fully exploited …

Bridging bio–nano science and cancer nanomedicine

M Bjornmalm, KJ Thurecht, M Michael, AM Scott… - ACS …, 2017 - ACS Publications
The interface of bio–nano science and cancer medicine is an area experiencing much
progress but also beset with controversy. Core concepts of the field eg, the enhanced …

Paclitaxel: What has been done and the challenges remain ahead

E Bernabeu, M Cagel, E Lagomarsino… - International journal of …, 2017 - Elsevier
In recent years, the nanotechnology has offered researchers the opportunity to solve the
problems caused by the vehicle of the standard and first formulation of paclitaxel (Taxol®) …

PhysiCell: An open source physics-based cell simulator for 3-D multicellular systems

A Ghaffarizadeh, R Heiland, SH Friedman… - PLoS computational …, 2018 - journals.plos.org
Many multicellular systems problems can only be understood by studying how cells move,
grow, divide, interact, and die. Tissue-scale dynamics emerge from systems of many …