Cancer cells are shaped through an evolutionary process of DNA mutation, cell selection
and population expansion. Early steps in this process are driven by a set of mutated driver …

The incidence of adenocarcinoma of the esophagus has been increasing in develo**
countries over the last three decades and probably reflects a genuine increase in the …

Esophageal cancer ranks sixth in cancer death. To explore its genetic origins, we conducted
exomic sequencing on 11 esophageal adenocarcinomas (EAC) and 12 esophageal …

It has been hypothesized that neoplastic progression develops as a consequence of an
acquired genetic instability and the subsequent evolution of clonal populations with …

Background: The adenomatous polyposis coli (APC) locus on chromosome 5q21–22 shows
frequent loss of heterozygosity (LOH) in esophageal carcinomas. However, the prevalence …

OBJECTIVES: Most patients with Barrett's esophagus do not progress to cancer, but those
who do seem to have markedly increased survival when cancers are detected at an early …

Combining whole genome amplification (WGA) methods with novel laser-based
microdissection techniques has made it possible to exploit recent progress in molecular …

In this era of the Human Genome Project, quantitation of gene expression in tumor or host
cells is of paramount importance for investigating the gene patterns responsible for cancer …

Supplement to “A framework for adaptive MCMC targeting multimodal distributions”. In
Supplementary Material A we present the proofs of our theoretical results of Section 3 and …

Neoplastic progression is an evolutionary process characterized by genomic instability and
waves of clonal expansions carrying genetic and epigenetic lesions to fixation (100% of the …