Antibacterial and antioxidant activities for natural and synthetic dual-active compounds

G Martelli, D Giacomini - European Journal of Medicinal Chemistry, 2018 - Elsevier
Antimicrobial resistance is widely recognized as a grave threat to global health in the 21st
century, since the past decades have seen a dramatic increase in human-pathogenic …

A review of the synthetic strategies toward spirobarbiturate-fused 3-to 7-membered rings

A Bagherinejad, A Alizadeh - Organic & Biomolecular Chemistry, 2022 - pubs.rsc.org
Spiro-connected hexahydropyrimidine-2, 4, 6-trione heterocyclic rings have received
increasing attention from the viewpoint of biological activity and synthetic methods due to the …

Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative …

J Figueiredo, JL Serrano, E Cavalheiro… - European journal of …, 2018 - Elsevier
Barbituric and thiobarbituric acid derivatives have become progressively attractive to
medicinal chemists due to their wide range of biological activities. Herein, different series of …

Electrochemical thiocyanation of barbituric acids

OV Bityukov, AS Kirillov, PY Serdyuchenko… - Organic & …, 2022 - pubs.rsc.org
The electrochemical thiocyanation of barbituric acids with NH4SCN was disclosed in an
undivided cell under constant current conditions. The electrosynthesis is the most efficient at …

Barbiturate- and Thiobarbituarte-Based s-Triazine Hydrazone Derivatives with Promising Antiproliferative Activities

H Al Rasheed, K Dahlous, A Sharma, E Sholkamy… - ACS …, 2020 - ACS Publications
A new class of compounds, which include s-triazine with pyrimidinetrione or
thiopyrimidinedione moiety through a hydrazone linkage, were synthesized and …

Hidden Reactivity of Barbituric and Meldrum's Acids: Atom-Efficient Free-Radical C–O Coupling with N-Hydroxy Compounds

IB Krylov, SA Paveliev, AS Budnikov, OO Segida… - …, 2021 - thieme-connect.com
The reactivity of CH-acidic and structurally related enol-containing heterocycles towards N-
oxyl radicals is disclosed. Traditionally, these substrates have been considered as reactants …

Graphene Oxide Incorporated Strontium Nanoparticles as a Highly Efficient and Green Acid Catalyst for One-Pot Synthesis of Tetramethyl-9-aryl-hexahydroxanthenes and 13-Aryl-5H …

SR Mousavi, H Rashidi Nodeh, E Zamiri Afshari… - Catalysis Letters, 2019 - Springer
An efficient, inexpensive and recyclable graphene oxide/strontium nanocatalyst was
synthesized and applied in a pseudo three-component, one-pot cyclocondensation of …

Visible light mediated, photocatalyst‐free condensation of barbituric acid with carbonyl compounds

S Kumari, S Kumar Maury, H Kumar Singh… - …, 2021 - Wiley Online Library
An economical and efficient method has been developed for the production of dibarbiturates
of oxindole and arylidene barbituric acid derivatives via condensation of of isatin/aryl …

Detailed theoretical characterization of azo chromophores containing dicyanomethylene acceptor and various coupling components by DFT

N Seferoğlu, G Toprakçıoğlu - Journal of Molecular Structure, 2019 - Elsevier
The structural, electronic and nonlinear optical (NLO) properties of a new series of donor-π-
acceptor (D-π-A) type azo dyes bearing strong electron-accepting dicyanomethylene unit …

Synthesis, structural characterization, and ADMET analysis of new pyrazol-pyrimidine derivatives

TM Mladenović, VM Matejić, SB Novaković… - Journal of Molecular …, 2025 - Elsevier
New pyrazol-pyrimidine derivatives were obtained starting from pyrazolone, barbituric acid,
and different substituted benzaldehydes, by reflux in a mixture of ethanol/water (1: 1) as a …