Advanced glycation end-products (AGEs): Formation, chemistry, classification, receptors, and diseases related to AGEs

A Twarda-Clapa, A Olczak, AM Białkowska… - Cells, 2022‏ - mdpi.com
Advanced glycation end-products (AGEs) constitute a non-homogenous, chemically diverse
group of compounds formed either exogeneously or endogeneously on the course of …

Epidemiology of peritoneal dialysis outcomes

AK Bello, IG Okpechi, MA Osman, Y Cho… - Nature Reviews …, 2022‏ - nature.com
Peritoneal dialysis (PD) is an important home-based treatment for kidney failure and
accounts for 11% of all dialysis and 9% of all kidney replacement therapy globally. Although …

Patient phenotype profiling in heart failure with preserved ejection fraction to guide therapeutic decision making. A scientific statement of the Heart Failure Association …

SD Anker, MS Usman, MS Anker… - European journal of …, 2023‏ - Wiley Online Library
Heart failure with preserved ejection fraction (HFpEF) represents a highly heterogeneous
clinical syndrome affected in its development and progression by many comorbidities. The …

The effects of type 2 diabetes mellitus on organ metabolism and the immune system

G Daryabor, MR Atashzar, D Kabelitz, S Meri… - Frontiers in …, 2020‏ - frontiersin.org
Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …

Methylglyoxal and its adducts: Induction, repair, and association with disease

SWT Lai, EDJ Lopez Gonzalez, T Zoukari… - Chemical research in …, 2022‏ - ACS Publications
Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

Advanced glycation end products (AGEs) may be a striking link between modern diet and health

V Gill, V Kumar, K Singh, A Kumar, JJ Kim - Biomolecules, 2019‏ - mdpi.com
The Maillard reaction is a simple but ubiquitous reaction that occurs both in vivo and ex vivo
during the cooking or processing of foods under high-temperature conditions, such as …

Circulating oxidative stress biomarkers in clinical studies on type 2 diabetes and its complications

E Bigagli, M Lodovici - Oxidative medicine and cellular …, 2019‏ - Wiley Online Library
Type 2 diabetes (T2DM) and its complications constitute a major worldwide public health
problem, with high rates of morbidity and mortality. Biomarkers for predicting the occurrence …

[HTML][HTML] Vascular effects of advanced glycation endproducts: clinical effects and molecular mechanisms

A Stirban, T Gawlowski, M Roden - Molecular metabolism, 2014‏ - Elsevier
The enhanced generation and accumulation of advanced glycation endproducts (AGEs)
have been linked to increased risk for macrovascular and microvascular complications …

Maillard reaction products derived from food protein-derived peptides: Insights into flavor and bioactivity

Y Fu, Y Zhang, OP Soladoye… - Critical reviews in food …, 2020‏ - Taylor & Francis
Food protein-derived peptides serve as food ingredients that can influence flavor and
bioactivity of foods. The Maillard reaction plays a crucial role in food processing and storage …

Gut microbiota, immune development and function

S Bengmark - Pharmacological research, 2013‏ - Elsevier
The microbiota of Westerners is significantly reduced in comparison to rural individuals
living a similar lifestyle to our Paleolithic forefathers but also to that of other free-living …