Control of adaptive immunity by the innate immune system
Microbial infections are recognized by the innate immune system both to elicit immediate
defense and to generate long-lasting adaptive immunity. To detect and respond to vastly …
defense and to generate long-lasting adaptive immunity. To detect and respond to vastly …
Caspase functions in cell death and disease
DR McIlwain, T Berger, TW Mak - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
Caspases are a family of endoproteases that provide critical links in cell regulatory networks
controlling inflammation and cell death. The activation of these enzymes is tightly controlled …
controlling inflammation and cell death. The activation of these enzymes is tightly controlled …
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
Inflammasomes are large cytoplasmic complexes that sense microbial infections/danger
molecules and induce caspase-1 activation-dependent cytokine production and …
molecules and induce caspase-1 activation-dependent cytokine production and …
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
Significance: Inflammasomes are multiprotein complexes localized within the cytoplasm of
the cell that are responsible for the maturation of proinflammatory cytokines such as …
the cell that are responsible for the maturation of proinflammatory cytokines such as …
Sensing and reacting to microbes through the inflammasomes
L Franchi, R Muñoz-Planillo, G Núñez - Nature immunology, 2012 - nature.com
Inflammasomes are multiprotein complexes that activate caspase-1, which leads to
maturation of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 and the …
maturation of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 and the …
Mechanisms of action of adjuvants
S Awate, LA Babiuk, G Mutwiri - Frontiers in immunology, 2013 - frontiersin.org
Adjuvants are used in many vaccines, but their mechanisms of action are not fully
understood. Studies from the past decade on adjuvant mechanisms are slowly revealing the …
understood. Studies from the past decade on adjuvant mechanisms are slowly revealing the …
Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: From mechanism to therapy
J Liu, X Han, T Zhang, K Tian, Z Li, F Luo - Journal of Hematology & …, 2023 - Springer
Inflammation is a fundamental defensive response to harmful stimuli, but the overactivation
of inflammatory responses is associated with most human diseases. Reactive oxygen …
of inflammatory responses is associated with most human diseases. Reactive oxygen …
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
Inflammasomes are a family of cytosolic multiprotein complexes that initiate innate immune
responses to pathogenic microbes by activating the caspase 1 protease,. Although genetic …
responses to pathogenic microbes by activating the caspase 1 protease,. Although genetic …
A novel conserved mechanism for plant NLR protein pairs: the “integrated decoy” hypothesis
S Cesari, M Bernoux, P Moncuquet, T Kroj… - Frontiers in plant …, 2014 - frontiersin.org
Plant immunity is often triggered by the specific recognition of pathogen effectors by
intracellular nucleotide-binding, leucine-rich repeat receptors (NLR). Plant NLRs contain an …
intracellular nucleotide-binding, leucine-rich repeat receptors (NLR). Plant NLRs contain an …
Pseudomonas aeruginosa in Chronic Lung Infections: How to Adapt Within the Host?
Bacteria that readily adapt to different natural environments, can also exploit this versatility
upon infection of the host to persist. Pseudomonas aeruginosa, a ubiquitous Gram-negative …
upon infection of the host to persist. Pseudomonas aeruginosa, a ubiquitous Gram-negative …