Open Search of Peptide Glycation Products from Tandem Mass Spectra

MT Berger, D Hemmler, P Diederich… - Analytical …, 2022 - ACS Publications
Identification of chemically modified peptides in mass spectrometry (MS)-based glycation
studies is a crucial yet challenging task. There is a need to establish a mode for matching …

Differentiation and quantitation of coeluting isomeric Amadori and Heyns peptides using sugar-specific fragment ion ratios

S Schmutzler, M Wölk, R Hoffmann - Analytical Chemistry, 2022 - ACS Publications
d-glucose and d-fructose present in blood, tissues, and organs of all mammals can react
with amino groups, leading to glucated (Amadori) and fructated (Heyns) products, ie …