Stochastic models of intracellular transport

PC Bressloff, JM Newby - Reviews of Modern Physics, 2013 - APS
The interior of a living cell is a crowded, heterogenuous, fluctuating environment. Hence, a
major challenge in modeling intracellular transport is to analyze stochastic processes within …

From first-passage times of random walks in confinement to geometry-controlled kinetics

O Bénichou, R Voituriez - Physics Reports, 2014 - Elsevier
We present a general theory which allows one to accurately evaluate the mean first-passage
time (FPT) for regular random walks in bounded domains, and its extensions to related first …

[ΒΙΒΛΙΟ][B] Stochastic processes in cell biology

PC Bressloff - 2014 - Springer
One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

The narrow escape problem

D Holcman, Z Schuss - siam REVIEW, 2014 - SIAM
The narrow escape problem in diffusion theory is to calculate the mean first passage time of
a diffusion process to a small target on the reflecting boundary of a bounded domain. The …

An asymptotic analysis of the mean first passage time for narrow escape problems: Part II: The sphere

AF Cheviakov, MJ Ward, R Straube - Multiscale Modeling & Simulation, 2010 - SIAM
The mean first passage time (MFPT) is calculated for a Brownian particle in a spherical
domain in R^3 that contains N small nonoverlap** absorbing windows, or traps, on its …

Stochastic narrow escape in molecular and cellular biology

D Holcman, Z Schuss - Analysis and Applications. Springer, New York, 2015 - Springer
This monograph consists of two main parts, mathematical and biological. The mathematical
part, which is quite sophisticated involving advanced asymptotic methods in partial …

From single-particle stochastic kinetics to macroscopic reaction rates: fastest first-passage time of N random walkers

DS Grebenkov, R Metzler, G Oshanin - New Journal of Physics, 2020 - iopscience.iop.org
We consider the first-passage problem for N identical independent particles that are initially
released uniformly in a finite domain Ω and then diffuse toward a reactive area Γ, which can …

Full distribution of first exit times in the narrow escape problem

DS Grebenkov, R Metzler, G Oshanin - New Journal of Physics, 2019 - iopscience.iop.org
In the scenario of the narrow escape problem (NEP) a particle diffuses in a finite container
and eventually leaves it through a small'escape window'in the otherwise impermeable …

Optimal reaction time for surface-mediated diffusion

O Bénichou, D Grebenkov, P Levitz, C Loverdo… - Physical review …, 2010 - APS
We present an exact calculation of the mean first-passage time to a small target on the
surface of a 2D or 3D spherical domain, for a molecule performing surface-mediated …

First passage statistics for the capture of a Brownian particle by a structured spherical target with multiple surface traps

AE Lindsay, AJ Bernoff, MJ Ward - Multiscale Modeling & Simulation, 2017 - SIAM
We study the first passage time problem for a diffusing molecule in an enclosed region to hit
a small spherical target whose surface contains many small absorbing traps. This study is …