In this Review, I present evidence supporting a multifactorial causation of childhood acute
lymphoblastic leukaemia (ALL), a major subtype of paediatric cancer. ALL evolves in two …

Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …

Derivation of CD7-targeted chimeric antigen receptor (7CAR) T cells often requires genetic
manipulations to ablate the CD7 gene or block CD7 cell surface expression. Our novel …

Genomic analysis has greatly influenced the diagnosis and clinical management of patients
affected by diverse forms of hematologic malignancies. Here, we review how genetic …

Differences in three-dimensional (3D) chromatin architecture can influence the integrity of
topologically associating domains (TADs) and rewire specific enhancer–promoter …

Successful adoptive T-cell immunotherapy of solid tumors will require improved expansion
and cytotoxicity of tumor-directed T cells within tumors. Providing recombinant or transgenic …

T-cell acute lymphoblastic leukemia (T-ALL) is a highly proliferative hematologic malignancy
that results from the transformation of immature T-cell progenitors. Aberrant cell growth and …

Acute lymphoblastic leukemia (ALL) is the most successful paradigm of how risk-adapted
therapy and detailed understanding of the genetic alterations driving leukemogenesis and …

T-cell acute lymphoblastic leukemias (T-ALL) are immature lymphoid tumors localizing in the
bone marrow, mediastinum, central nervous system, and lymphoid organs. They account for …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignant leukemia with
extremely limited treatment for relapsed patients. N6‐methyladenosine (m6A) reader insulin …