With the development of modern high-throughput omic measurement platforms, it has
become essential for biomedical studies to undertake an integrative (combined) approach to …

Pathway enrichment analysis is indispensable for interpreting omics datasets and
generating hypotheses. However, the foundations of enrichment analysis remain elusive to …

Pathway analysis is often the first choice for studying the mechanisms underlying a
phenotype. However, conventional methods for pathway analysis do not take into account …

Cyclic adenosine monophosphate (cAMP) is a key second messenger that regulates signal
transduction pathways pivotal for numerous biological functions. Intracellular cAMP levels …

Essential hypertension is a common, complex disorder affecting≤ 1 billion adults globally.
Blood pressure is a highly heritable trait, with≤ 50% of the variation between individuals …

We describe a “gel‐assisted” proteomic sample preparation method for MS analysis.
Solubilized protein extracts or intact cells are copolymerized with acrylamide, facilitating …

Introduction: Protein-protein interactions are important for biological processes and
pathological situations, and are attractive targets for drug discovery. However, rational drug …

Over the last decade, gene set analysis has become the first choice for gaining insights into
underlying complex biology of diseases through gene expression and gene association …

Parkinson's disease (PD) arises as neurodegenerative disorder and characterized by
progressive deterioration of motor functions due to forfeiture of dopamine-releasing neurons …

Tuberculosis (TB) is a deadly infectious disease that affects millions of people globally. TB
proteomics signature discovery has been a rapidly growing area of research that aims to …