Intercellular signaling molecules, known as morphogens, act at a long range in develo**
tissues to provide spatial information and control properties such as cell fate and tissue …

Cell type-and differentiation-specific gene expression is precisely controlled by genomic non-
coding regulatory elements (NCREs), which include promoters, enhancers, silencers and …

INTRODUCTION What determines the pace of embryonic development? Although the
molecular and cellular mechanisms of many developmental processes are evolutionarily …

The vertebrate spinal cord comprises multiple functionally distinct neuronal cell types
arranged in characteristic positions. During development, these different types of neurons …

The Drosophila blastoderm and the vertebrate neural tube are archetypal examples of
morphogen-patterned tissues that create precise spatial patterns of different cell types. In …

Like many develo** tissues, the vertebrate neural tube is patterned by antiparallel
morphogen gradients. To understand how these inputs are interpreted, we measured …

Tissue patterning during animal development is orchestrated by a handful of inductive
signals. Most of these developmental cues act as morphogens, meaning they are locally …

In the vertebrate neural tube, the morphogen Sonic Hedgehog (Shh) establishes a
characteristic pattern of gene expression. Here we quantify the Shh gradient in the …

The development of the vertebrate spinal cord involves the formation of the neural tube and
the generation of multiple distinct cell types. The process starts during gastrulation …

In many develo** tissues, the patterns of gene expression that assign cell fate are
organized by graded secreted signals. Cis-regulatory elements (CREs) interpret these …